Acetylsalicylic acid pills 500 mg, 20 pcs.

Composition

1 tablet contains:

Active ingredient:

acetylsalicylic acid 500 mg

. excipients:

potato starch,

stearic acid,

citric acid,

talc.

Pharmacological action

Pharmaceutical Group:

NSAIDs.

Pharmacology:

NSAIDs; have anti-inflammatory, analgesic and antipyretic effects associated with the indiscriminate inhibition of COX and COX-2 activity, which regulate the synthesis of PG. As a result, PG is not formed, which ensures the formation of edema and hyperalgesia. A decrease in the PH content (mainly E1) in the thermoregulatory center leads to a decrease in body temperature due to vasodilation of the skin and increased sweating.

The analgesic effect is due to both central and peripheral action.

Reduces platelet aggregation, adhesion and thrombosis by suppressing the synthesis of thromboxane A2 in platelets. The antiplatelet effect persists for 7 days after a single dose (more pronounced in men than in women). Reduces mortality and risk of myocardial infarction in unstable angina.

It is effective in the primary prevention of cardiovascular diseases, especially myocardial infarction in men over 40 years of age, and in the secondary prevention of myocardial infarction. In a daily dose of 6 g or more, it suppresses the synthesis of prothrombin in the liver and increases the prothrombin time.

Increases the fibrinolytic activity of plasma and reduces the concentration of vitamin K-dependent coagulation factors (II, VII, IX, X). Increases the frequency of hemorrhagic complications during surgical interventions, increases the risk of bleeding during anticoagulant therapy.

It stimulates the excretion of uric acid (disrupts its reabsorption in the renal tubules), but in high doses. Blockade of COX in the gastric mucosa leads to inhibition of gastroprotective Pg, which can cause ulceration of the mucous membrane and subsequent bleeding.

Dosage forms containing buffers, enteric-soluble membranes, as well as special “effervescent” forms of tablets have a less irritating effect on the gastrointestinal mucosa.

Indications

Symptomatic treatment of pain: headache (including withdrawal symptoms), toothache, sore throat, back and muscle pain, joint pain, pain during menstruation.

Elevated body temperature in colds and other infectious and inflammatory diseases (in adults and children over 15 years of age).

Contraindications

• Hypersensitivity to acetylsalicylic acid and other nonsteroidal anti-inflammatory drugs or other components of the drug;
• erosive-ulcerative lesions of the gastrointestinal tract (in acute phase), gastrointestinal bleeding;
• asthma induced by ingestion of salicylates and nonsteroidal anti-inflammatory drugs;
• hemorrhagic diathesis;

– the combined use of methotrexate in a dose of 15 mg per week or more;

pregnancy, lactation;

• the combination of bronchial asthma, recurrent polyposis of the nose and paranasal sinuses and intolerance of acetylsalicylic acid;
• children under 12 years (for this dosage form)

The drug is not prescribed to children under 15 years of age with acute respiratory diseases caused by viral infections, because of the risk of developing Reye’s syndrome (encephalopathy and acute fatty liver with acute development of liver failure).

With caution

With concomitant anticoagulant therapy, gout, stomach and/or duodenal ulcer (in the anamnesis), including chronic or recurrent peptic ulcer disease, or episodes of gastrointestinal bleeding; renal and/or hepatic insufficiency, glucose-6-phosphate dehydrogenase deficiency; hyperuricemia, bronchial asthma, chronic obstructive pulmonary disease, hay fever, nasal polyposis, drug allergy, concomitant use of methotrexate at a dose of less than 15 mg/week, pregnancy.

Side effects

• From the gastrointestinal tract: abdominal pain, heartburn, nausea, vomiting, obvious (vomiting with blood, tarry stools) or hidden signs of gastrointestinal bleeding, which can lead to iron deficiency anemia, erosive and ulcerative lesions (including perforation) of the gastrointestinal tract, isolated cases-liver function disorders (increased liver transaminases).

• From the central nervous system: dizziness, tinnitus (usually signs of overdose).

• From the hematopoietic system: increased risk of bleeding, which is a consequence of the effect of acetylsalicylic acid on platelet aggregation.

• Allergic reactions: skin rash, anaphylactic reactions, bronchospasm, angioedema.

If such symptoms occur, it is recommended to stop taking the drug and immediately consult your doctor.

Interaction

Shared application:

• with methotrexate at a dose of 15 mg per week or more increased hemolytic cytotoxicity of methotrexate (decreased renal clearance of methotrexate and methotrexate is substituted salicylates in connection with blood plasma proteins);

• anticoagulants, for example, with heparin: increased risk of bleeding due to inhibition of platelet function, damage to the mucosa of the gastrointestinal tract, displacing anticoagulants (oral) from the blood plasma;

• with other nonsteroidal anti-inflammatory drugs: as a result of synergistic interaction increases the risk of ulcers and bleeding of the stomach;

• with uricosuric drugs, such as benzbromarone: reduces uricosuric effect;

• digoxin: digoxin concentration increased because of the reduced renal excretion;

• with hypoglycemic drugs such as insulin: increased hypoglycemic effect of hypoglycemic drugs due to the hypoglycemic action of the acetylsalicylic acid;

• drugs of the group of thrombolytics: the risk of bleeding increases;

• with systemic corticosteroids, except hydrocortisone, used as replacement therapy in Addison’s disease: the use of corticosteroids reduces the level of salicylates in the blood by increasing excretion of the latter;

• with angiotensin-converting enzyme: reduced glomerular filtration due to the inhibition of prostaglandins and, as a consequence, decreased antihypertensive effect;

• with valproic acid: increases toxicity of valproic acid;

• ethanol (alcoholic beverages): increases the risk of damaging effects on the mucous membranes of the gastrointestinal tract and increases the risk of gastrointestinal bleeding;

• enhances the effects of narcotic analgesics, of thrombolytics and thrombocyte aggregation inhibitors, sulfonamides (including co-trimoxazole);

• increases the concentration of barbiturates, lithium salts in the plasma;

• antacids containing magnesium and/or aluminum, slow down and reduce the absorption of acetylsalicylic acid;

• myelotoxic drugs increase the manifestation gematotoksichnosti of the drug.

How to take, course of administration and dosage

Inside, adults and children over 12 years of age: a single dose is 0.25-0.5 g, the maximum single dose is 1.0 g (2 tablets of 0.5 g), the maximum daily dose is 3.0 g (6 tablets of 0.5 g) a single dose, if necessary, can be taken 3-4 times a day with an interval of at least 4 hours. Children, with the exception of acute respiratory diseases caused by viral infections, due to the risk of developing Reye’s syndrome (encephalopathy and acute fatty liver with acute development of liver failure): a single dose for children aged from 3 years is 0.125 g (1/2 tablet 250 mg), starting from 6 years of age, you can prescribe in tablets of 0.25 g per reception.

The drug should be taken after a meal, washed down with water, milk or alkaline mineral water. Frequency and time of administration: a single dose, if necessary, can be taken 3-4 times a day with an interval of at least 4 hours. Regular adherence to the drug regimen allows you to avoid a sharp increase in temperature and reduce the intensity of pain. The duration of treatment (without consulting a doctor) should not exceed 7 days when prescribed as an analgesic and more than 3 days – as an antipyretic.

Overdose

Symptoms: Moderate overdose: nausea, vomiting, tinnitus, hearing loss, headache, dizziness and confusion. These symptoms disappear when the dose of the drug is reduced.

Severe overdose: fever, hyperventilation, ketoacidosis, respiratory alkalosis, metabolic acidosis, coma, cardiogenic shock, respiratory failure, severe hypoglycemia.

Treatment: hospitalization, gastric lavage, administration of activated charcoal, monitoring of acid-base balance, alkaline diuresis in order to obtain a urine pH between 7.5-8 (forced alkaline diuresis is considered achieved if the concentration of salicylate in the blood plasma is more than 500 mg/l (3.6 mmol/l) in adults or 300 mg / l (2.2 mmol/l) in children), hemodialysis, compensation for fluid loss, symptomatic therapy.

Special instructions

Acetylsalicylic acid may cause bronchospasm, an attack of bronchial asthma, or other hypersensitivity reactions.Risk factors include the presence of bronchial asthma, nasal polyps, fever, chronic bronchopulmonary diseases, and a history of allergies (allergic rhinitis, skin rashes).

Acetylsalicylic acid may increase the tendency to bleed due to its inhibitory effect on platelet aggregation. This should be taken into account when surgical procedures are needed, including minor interventions such as tooth extraction. Before surgery, to reduce bleeding during the operation and in the postoperative period, you should stop taking the drug for 5-7 days and inform the doctor.

Children should not be prescribed medications containing acetylsalicylic acid, because in the case of a viral infection, the risk of Reye’s syndrome increases. Symptoms of Reye’s syndrome include prolonged vomiting, acute encephalopathy, and enlarged liver.

If it is necessary to use the drug during lactation, breastfeeding should be discontinued.

In the treatment of vascular diseases, the daily dose of acetylsalicylic acid ranges from 75 to 300 mg

. Acetylsalicylic acid reduces the excretion of uric acid from the body, which can cause an acute attack of gout in predisposed patients.

There was no effect of taking the drug on driving a motor vehicle and other mechanisms.

Form of production

Tablets

Storage conditions

Store in a dry place, at a temperature not exceeding 25 ° C. Keep out of reach of children.

Shelf

life is 4 years.

Active ingredient

Acetylsalicylic acid

Dosage form

Tablets

Purpose

Children over 15 years of age, For adults, Pregnant Women only in the second trimester as prescribed by a doctor

Indications

Hangover, Rheumatoid Arthritis, Migraines, Colds, Arthrosis and Arthritis

Weight

Weight: 24 gr.