Actovegin solution for injection, 40 mg/ml ampoules 10 ml 5 pcs.
Manufacturer: Takeda Pharmaceuticals LLC, Russia
$74.00
| Active ingredient: | |
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| Dosage form: | |
| Indications for use: | Acquired dementia, Bedsores, Burns, Concussion and other brain injuries, Impaired cerebral circulation, Stroke sequelae, Trophic ulcers, Wounds |
Indications
Indications
- metabolic and vascular disorders of the brain (including ischemic stroke, traumatic brain injury);
- wound healing (ulcers of various etiologies, burns, trophic disorders (bedsores), violation of wound healing processes);
- prevention and treatment of radiation lesions of the skin and mucous membranes during radiation therapy.
- peripheral (arterial and venous) vascular disorders and their consequences (arterial angiopathy, trophic ulcers);
Dosage
How to take, course of administration and dosage
IV, IV (including in the form of infusion) and IV. Due to the potential for anaphylactic reactions, it is recommended to perform the test before starting the infusion.
Depending on the severity of the clinical picture,10-20 ml / day IV or iv; then 5 ml IV or 5 ml iv.
When administered as an infusion,10-20 ml of Actovegin®is added to 200-300 ml of the main solution (0.9% sodium chloride solution or 5% dextrose solution). Rate of administration: about 2 ml/min.
Metabolic and vascular disorders of the brain: at the beginning of treatment,10 ml iv daily for two weeks, then 5-10 ml iv 3-4 times a week for at least 2 weeks.
Ischemic stroke: 20-50 ml in 200-300 ml of the main solution IV drip daily for 1 week, then 10-20 ml IV drip for 2 weeks.
Peripheral (arterial and venous) vascular disorders and their consequences: 20-30 ml of the drug in 200 ml of the main solution IV or IV daily; the duration of treatment is about 4 weeks.
Wound healing: 10 ml iv or 5 ml iv daily or 3-4 times a week depending on the healing process (in addition to topical treatment with Actovegin® in dosage forms for topical use).
Prevention and treatment of radiation damage to the skin and mucous membranes during radiation therapy: the average dose is 5 ml iv daily during breaks in radiation exposure.
Radiation cystitis: daily 10 ml transurethral in combination with antibiotic therapy.
Contraindications
Contraindications
- hypersensitivity to Actovegin® or similar medications;
- decompensated heart failure;
- pulmonary edema;
- oliguria, anuria;
- fluid retention in the body.
- With caution: hyperchloremia, hypernatremia.
Composition
Composition
1 ampoule contains:
active substance:
Actovegin ® concentrate (based on dry deproteinized calves ‘ blood hemoderivate) 1) – 400.0 mg;
auxiliary substance:
water for injection-up to 10 ml
.1) Actovegin ® concentrate contains sodium chloride in the form of sodium and chlorine ions, which are components of calves ‘ blood. Sodium chloride is not added or removed during the concentrate production process.
The sodium chloride content is about 53.6 mg (for 2 ml ampoules), about 134.0 mg (for 5 ml ampoules) and about 268.0 mg (for 10 ml ampoules).
Composition
1 ampoule contains:
Active ingredient:
Actovegin ® concentrate (based on dry deproteinized calves ‘ blood hemoderivate) 1) – 400.0 mg;
auxiliary substance:
water for injection-up to 10 ml
.1) Actovegin ® concentrate contains sodium chloride in the form of sodium and chlorine ions, which are components of calves ‘ blood. Sodium chloride is not added or removed during the concentrate production process.
The sodium chloride content is about 53.6 mg (for 2 ml ampoules), about 134.0 mg (for 5 ml ampoules) and about 268.0 mg (for 10 ml ampoules).
Pharmacological action
Actovegin has a positive effect on glucose transport and utilization, stimulates oxygen consumption (which leads to stabilization of the plasma membranes of cells in ischemia and reduces the formation of lactates), thus having an antihypoxic effect, which begins to manifest itself no later than 30 minutes (10-30 minutes) after parenteral administration and reaches a maximum and average in 3 hours (2-6 hours).
Actovegin increases the concentrations of ATP, LDF, phosphocreatine, and the amino acids glutamate, aspartate, and GABA.
The use of Actovegin to accelerate wound healing is also based on the data mentioned above. At the same time, not only morphological, but also biochemical parameters of granulations are improved – the concentration of DNA, hemoglobin and hydroxyproline increases.
Indications
- metabolic and vascular disorders of the brain (including ischemic stroke, traumatic brain injury);
- wound healing (ulcers of various etiologies, burns, trophic disorders (bedsores), violation of wound healing processes);
- prevention and treatment of radiation lesions of the skin and mucous membranes during radiation therapy.
- peripheral (arterial and venous) vascular disorders and their consequences (arterial angiopathy, trophic ulcers);
Contraindications
- hypersensitivity to Actovegin® or similar medications;
- decompensated heart failure;
- pulmonary edema;
- oliguria, anuria;
- fluid retention in the body.
- With caution: hyperchloremia, hypernatremia.
Side effects
Allergic reactions (skin rash, skin hyperemia, hyperthermia) up to anaphylactic shock.
Interaction
Currently unknown.
How to take, course of administration and dosage
IV, IV (including in the form of infusion) and IV. Due to the potential for anaphylactic reactions, it is recommended to perform the test before starting the infusion.
Depending on the severity of the clinical picture,10-20 ml / day IV or iv; then 5 ml IV or 5 ml iv.
When administered as an infusion,10-20 ml of Actovegin®is added to 200-300 ml of the main solution (0.9% sodium chloride solution or 5% dextrose solution). Rate of administration: about 2 ml/min.
Metabolic and vascular disorders of the brain: at the beginning of treatment,10 ml iv daily for two weeks, then 5-10 ml iv 3-4 times a week for at least 2 weeks.
Ischemic stroke: 20-50 ml in 200-300 ml of the main solution IV drip daily for 1 week, then 10-20 ml IV drip for 2 weeks.
Peripheral (arterial and venous) vascular disorders and their consequences: 20-30 ml of the drug in 200 ml of the main solution IV or IV daily; the duration of treatment is about 4 weeks.
Wound healing: 10 ml iv or 5 ml iv daily or 3-4 times a week depending on the healing process (in addition to topical treatment with Actovegin® in dosage forms for topical use).
Prevention and treatment of radiation damage to the skin and mucous membranes during radiation therapy: the average dose is 5 ml iv daily during breaks in radiation exposure.
Radiation cystitis: daily 10 ml transurethral in combination with antibiotic therapy.
Special instructions
Due to the possibility of an anaphylactic reaction, a test injection (2 ml intramuscularly) is recommended.
The solution for injection has a slightly yellowish tint. The color intensity may vary from one batch to another depending on the characteristics of the raw materials used, but this does not adversely affect the activity of the drug or its tolerability.
In the case of an intramuscular method of administration, no more than 5 ml is administered slowly.
Do not use an opaque solution or a solution containing particles. After opening the ampoule, the solution should not be stored.
Form of production
The solution for injection is clear, yellowish, practically free of particles.
Storage conditions
At a temperature not exceeding 25°C in a place protected from light. Keep out of reach of children!
Shelf
life is 3 years. Do not use after the expiration date.
Active ingredient
Deproteinized calves ‘ blood hemoderivate
Conditions of release from pharmacies
By prescription
Dosage form
solution for injection
Description
For adults as prescribed by a doctor, for pregnant women as prescribed by a doctor
Indications
Consequences of stroke, Acquired dementia, Concussion and other traumatic brain injuries, Wounds, Trophic ulcers, Burns, Pressure sores, Cerebral circulation disorders
Weight
Weight: 24 gr.
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