Dibazol (Bendazol) tablets, injections

Dibazole

Active ingredient is Bendazole.

Description:

Antispasmodic myotropic medication, Dibazole, is a derivative of benzimidazole. It produces antispasmodic effect on smooth muscles of blood vessels and inner organs. Dibazole decreases blood pressure by lowering cardiac output and expanding peripheral vessels. Hypotensive activity of bendazole is moderate, and the effect does not last. Dibazole produces short expansion of brain vessels and alleviates synaptic transmission in spinal cord.

Immunostimulating activity of Dibazole is directly connected to regulation of cGMP and cAMP correlations in immune cells (cGMP increases). It produces proliferation of mature sensitized T and B lymphocytes (secretion of mutual regulation factors, cooperative reaction and activation of ultimate effector cells function).

Uses:

• Arterial hypertension
• Arterial spasms (coronary vasospasm, peripheral artery spasm)
• Smooth muscles of inner organs spasm (stomach and duodenum ulcer, intestinal colic)
• Nervous system disorder (residual poliomyelitis, peripheral paralysis of cranial nerve)

Directions:

Tablets:

Adults: take 20-50mg 2-3 times a day during 3-4 weeks

Nervous system disorders:

Adults: 5mg 1 time a day or every other day during 5-10 days. The course of treatment may be repeated in 3-4 weeks. In the future the course of treatment is conducted with 1-2 moths interval.

Children as advised by a doctor: 1-5mg 1 time a day.

Injections:

Reduction of hypertensic crisis: intravenous or intramuscular 30-40mg

Aggravation of arterial hypertension with significant blood pressure hike – intramuscular 20-30mg 2-3 times a day. The course of treatment is 8-14 days

Side effects:

• Allergic reactions
• If taken for extended time: low rates of electrocardiogram test due to the decrease of cardiac output
• If taken in large dosage: fever, excessive sweating, dizziness, nausea, headache

When pregnant or breast-feeding:

A doctor may prescribe the medication if the expected benefit for mother is higher than risks for fetus.

When breast-feeding, ask a health professional before use.

Warnings:

• Hyper sensitivity to bendazole
• Take with caution if you are a senior patient. Do not use for extended time to treat arterial hypertension in elderly patients.

Interaction with other medications:

Simultaneous intake of diuretic substances with antihypertensic medications may cause intensification of antihypertensic effects.

Simultaneous intake of bendazole prevents general peripheral vascular resistance caused by beta-adrenoceptor antagonist.

Simultaneous intake with phentolamine intensifies bendazole hypotensive effects.

Dibazole is a vasodilating medication with hypotensive and antispasmodic effects.