Amixin, pills 125 mg, 10 pcs.

Composition

Tilorone – 60.0 mg or 125.0 mg.

Auxiliary substances:

core: potato starch – 25,500 mg or 46,000 mg, microcrystalline cellulose – 60,000 mg or 120,000 mg, povidone (povidone K 30) – 1,500 mg or 3,000 mg, calcium stearate – 1,500 mg or 3,000 mg, croscarmellose (croscarmellose sodium) – 1,500 mg or 3,000 mg;

shell: hypromellose (hydroxypropyl methylcellulose) -3,4050 mg or 6,8100 mg, titanium dioxide – 1,7815 mg or 3,5630 mg, macrogol (polyethylene glycol-4000)- 0,4565 mg or 0,9130 mg, Polysorbate-80 (tween-80) – 0,0570 mg or 0,1140 mg, dye quinoline yellow (E 104) – 0,1235 mg or 0,2470 mg, criteriamany sunset yellow (E 110) – 0,1765 mg or mg.0,3530

Pharmacological action

ATX code: J05 AH

Pharmacological properties

Pharmacodynamics.

Low molecular weight synthetic interferon inducer that stimulates the formation of all types of interferons (alpha, beta, gamma and lambda) in the body.

The main producers of interferon in response to the introduction of tiloron are intestinal epithelial cells, hepatocytes, T-lymphocytes, neutrophils and granulocytes. After oral administration, the maximum production of interferon is determined in the gut – liver – blood sequence after 4-24 hours. Amixin® has an immunomodulatory and antiviral effect.

According to experimental studies, after a single oral administration of Amixin® at a dose equivalent to the maximum daily dose for humans, the maximum concentration in the lung tissue of interferon lambda is determined after 24 hours, interferon alpha – after 48 hours.

Induction of interferon lambda in the lung tissue increases the antiviral protection of the respiratory tract in influenza and other respiratory viral infections.

In human leukocytes, it induces the synthesis of interferon. It stimulates bone marrow stem cells, increases antibody formation depending on the dose, reduces the degree of immunosuppression, and restores the ratio of T-suppressors and T-helpers.

It is effective against various viral infections, including influenza viruses, other acute respiratory viral infections, hepatitis viruses and herpesviruses. The mechanism of antiviral action is associated with the inhibition of translation of virus-specific proteins in infected cells, as a result of which viral reproduction is suppressed.

Pharmacokinetics.

After oral administration, it is rapidly absorbed from the gastrointestinal tract. Bioavailability – 60%. About 80% of the drug binds to plasma proteins. The drug is excreted almost unchanged through the intestines (70%) and through the kidneys (9%). The elimination half-life (T_1/2) is 48 hours. The drug does not undergo biotransformation and does not accumulate in the body.

Indications

As part of complex therapy:

For children from 7 to 18 years of age:

– treatment of influenza and other acute respiratory viral infections (ARVI).

For adults:

– treatment of influenza and other acute respiratory infections;

– treatment of herpes infection.

Prevention of influenza and other acute respiratory viral infections in adults.

Use during pregnancy and lactation

The use of the drug in pregnancy is contraindicated. If it is necessary to use the drug during lactation, breast-feeding should be discontinued.

Contraindications

Hypersensitivity to tilorone or any other component of the drug. Pregnancy and breast-feeding period. Children under 7 years of age (for a dosage of 60 mg), children under 18 years of age (for a dosage of 125 mg).

Side effects

Possible allergic reactions, dyspeptic phenomena, short-term chills. If any of the side effects listed in the instructions get worse, or you notice any other side effects not listed in the instructions, tell your doctor.

Interaction

It is compatible with antibiotics and drugs for the traditional treatment of viral and bacterial diseases. There was no clinically significant interaction of Amixin with antibiotics and traditional treatments for viral and bacterial diseases.

How to take, course of administration and dosage

Amixin®is taken orally, after meals.

For children from 7 to 18 years old:

For uncomplicated forms of influenza and other acute respiratory viral infections-60 mg 1 time a day on the 1st,2nd and 4th day from the start of treatment. The course dose is 180 mg (3 tablets).

For adults:

For the treatment of influenza and other acute respiratory infections-125 mg per day for the first 2 days of treatment, then 125 mg after 48 hours. For the course-750 mg (6 tablets).

For the prevention of influenza and other acute respiratory viral infections-125 mg 1 time a week for 6 weeks. For the course-750 mg (6 tablets).

For the treatment of herpetic infection – the first two days of 125 mg, then after 48 hours of 125 mg. The course dose is 1.25-2.5 g (10-20 tablets).

In the treatment of influenza and other acute respiratory viral infections, if symptoms persist for more than 4 days, you should consult a doctor.

Overdose

To date, cases of overdose of the drug Amixin are unknown.

Special instructions

Influence on the ability to drive vehicles and mechanisms

The drug does not have a negative effect on the ability to drive vehicles and engage in other potentially dangerous activities that require increased concentration of attention and speed of psychomotor reactions.

Form of production

Coated tablets.

Storage conditions

Store in a dry place, protected from light, at a temperature not exceeding 30 °C

Shelf life

3 years

Active ingredient

Tiloron

Dosage form

Tablets

Description

For adults

Indications

Prevention of flu and colds, Herpes, Tuberculosis, Common cold, Cytomegalovirus infection, Chlamydia, Hepatitis, Flu

Weight

Weight: 24 gr.