Biosulin N suspension for subcutaneous injection 100 IU/ml cartridge 3 ml 5 pcs.

Composition

1 ml of suspension for subcutaneous administration contains:

Active ingredient:

isofan-human insulin 100 UNITS

Pharmacological action

Biosulin H is a medium-acting insulin preparation. It is a human insulin produced using recombinant DNA technology.

It interacts with a specific receptor of the outer cytoplasmic membrane of cells and forms an insulin-receptor complex that stimulates intracellular processes, including the synthesis of a number of key enzymes (including hexokinase, pyruvate kinase, glycogen synthetase).

The decrease in blood glucose is caused by an increase in its intracellular transport, increased absorption and assimilation by tissues, stimulation of lipogenesis, glycogenogenesis, and a decrease in the rate of glucose production by the liver.

The duration of action of Biosulin H is mainly determined by the rate of absorption, which depends on several factors (for example, on the dose, method and place of administration), and therefore the profile of insulin action is subject to significant fluctuations, both in different and in the same patient.

Indications

— type 1 diabetes mellitus (insulin-dependent);— type 2 diabetes mellitus (non-insulin dependent): stage of resistance to oral hypoglycemic agents, partial resistance to these drugs (during combination therapy), intercurrent diseases.

Use during pregnancy and lactation

Data on the use of the drug during pregnancy and lactation are not provided.

Contraindications

-hypoglycemia— – hypersensitivity to insulin or other components of the drug Biosulin N.

Side effects

From the side of metabolism: hypoglycemic conditions (pallor of the skin, increased sweating, palpitation, tremor, hunger, agitation, paresthesia in the mouth, headache). Severe hypoglycemia can lead to the development of hypoglycemic coma.

Allergic reactions: rarely-skin rash, angioedema; in some cases-anaphylactic shock.

Local reactions: hyperemia, swelling and itching at the injection site; with prolonged use – lipodystrophy at the injection site. Other services: edema, transient refractive errors (usually at the beginning of therapy).

Interaction

There are a number of medications that affect the need for insulin.

The hypoglycemic effect of insulin is enhanced by oral hypoglycemic drugs, MAO inhibitors, non-selective beta-blockers, ACE inhibitors, sulfonamides, anabolic steroids, carbonic anhydrase inhibitors, bromocriptine, octreotide, tetracyclines, clofibrate, ketoconazole, mebendazole, pyridoxine, theophylline, cyclophosphamide, fenfluramine, lithium preparations, preparations containing ethanol.

The hypoglycemic effect of insulin is reduced by oral contraceptives, corticosteroids, thyroid hormones, thiazide diuretics, heparin, tricyclic antidepressants, sympathomimetics, danazol, clonidine, calcium channel blockers, diazoxide, morphine, phenytoin, nicotine. Under the influence of reserpine and salicylates, both a weakening and an increase in the effect of the drug is possible.

How to take, course of administration and dosage

The dose of Biosulin H is determined by the doctor individually, in each specific case, based on the level of glucose in the blood. The drug is intended for subcutaneous administration.

The average daily dose varies from 0.5 to 1 IU / kg of body weight (depending on the individual characteristics of the patient and the level of glucose in the blood).

Overdose

Symptoms: hypoglycemia may occur.

Treatment: the patient can eliminate mild hypoglycemia by taking sugar or carbohydrate-rich foods inside (patients with diabetes are advised to constantly carry sugar, sweets, cookies or sweet fruit juice). In severe cases, with loss of consciousness,40% dextrose solution is administered intravenously; intravenously, subcutaneously or intravenously – glucagon.

After regaining consciousness, the patient is recommended to take a carbohydrate-rich diet to prevent the recurrence of hypoglycemia.

Special instructions

You can not use the drug Biosulin H, if after shaking the suspension does not become white and evenly cloudy.

During insulin therapy, constant monitoring of blood glucose levels is necessary.

Form of production

Suspension for subcutaneous administration

Storage conditions

The drug should be stored out of the reach of children, protected from light at a temperature of 2° to 8°C; do not freeze.

Active ingredient

Human genetically engineered insulin isophane

Conditions of release from pharmacies

By prescription

Dosage form

suspension for injection

Description

For adults as prescribed by a doctor, Pregnant women as prescribed by a doctor, Nursing mothers as prescribed by a doctor, Children as prescribed by a doctor

Indications

Type 2 Diabetes, Type 1 Diabetes

Weight

Weight: 62 gr.