ATP (adenosine triphosphate) ampoules 1ml (10mg), N10

The active ingredient of ATP is sodium triphosphate, the molecule of which (adenosine-5-triphosphate) is obtained from animal muscle tissue. In addition, it is composed of potassium and magnesium ions, histidine, which is an important amino acid that takes part in the restoration of damaged tissues and is necessary for the proper development of the organism during its growth.

What ATP is needed for.

ATP is a macroergic (able to accumulate and transmit power) compound that is produced in the human body through various oxidation reactions and in the breakdown of carbohydrates. It is contained in almost all tissues and organs, but most of all – in skeletal muscle.

The role of ATP is improvement of energy and tissue metabolism. Splitting into ADP and inorganic phosphate, adenosine triphosphate releases energy that is used for muscle contraction and synthesis of protein, urea and intermediate metabolic products.

The relaxation of smooth muscles occurs, blood pressure reduces, the conduction of nerve impulses improves, myocardial contractility increases under the influence of this substance.

Given the above, the lack of ATP causes a number of diseases, such as dystrophy, cerebral circulatory disorders, coronary heart disease, etc.

 The pharmacological properties of ATP.

Thanks to the original structure, the molecule adenosine has unique pharmacological effects, that are not inherent to any other chemical components. ATP normalizes the concentration of magnesium and potassium ions, thus reducing the concentration of uric acid. By stimulating the energy metabolism it improves:

• activity of ion-transport systems of cell membranes;
• indicators of the lipid composition of the membranes;
• antioxidant defense system of the myocardium;
• activity of membrane dependent enzymes.

Due to the normalization of metabolic processes in the myocardium, caused by hypoxia and ischemia, ATP has antiarrhythmic, membrane-stabilizing and anti-ischemic effects.

Also, this drug improves:

• Myocardial contractility;
• Functional condition of the left ventricle;
• Indicators of the peripheral and central hemodynamics;
• Coronary circulation;
• Cardiac output (resulting in enhanced physical performance).

The role of ATP in ischemia is to decrease consumption of oxygen by the myocardium, activate the functional state of the heart, resulting in reduced breathlessness during physical activity and reduced frequency of angina attacks.

The medicine restores sinus rhythm and decreases the activity of ectopic foci in patients with supraventricular and paroxysmal supraventricular tachycardia and in patients with atrial fibrillation and flutter.

 Indications for the use of ATP:

• Coronary heart disease;
• Postinfarction and myocarditic cardiosclerosis;
• Unstable stenocardia;
• Supraventricular and paroxysmal supraventricular tachycardia;
• Rhythm disorders of various origins (in the complex treatment);
• Vegetative disorders;
• Hyperuricemia of different origin;
• Microcardiodystrophy ;
• Chronic fatigue syndrome.

The use of intramuscular ATP is beneficial in the following deseases:

• Polio;
• Muscular dystrophy and atony;
• Retinitis pigmentosa;
• Multiple sclerosis;
• Weakness of labor;
• Peripheral vascular disease (thromboangiitis obliterans, Raynaud’s disease);
• Intermittent claudication;

The drug is administered intravenously with the purpose to release paroxysms of supraventricular tachycardias.

 Contraindications for the use of ATP.

ATP should not be used by patients with hypersensitivity to any of its components, children, pregnant and lactating women, together with cardiac glycosides in high doses.

Also, it is not prescribed to patients who have been diagnosed with:

• hypomagnesemia;
• Hyperkalemia;
• Acute myocardial infarction;
• Severe form of bronchial asthma and other pulmonary inflammatory diseases;
• AV-block of second and third degree;
• Hemorrhagic stroke;
• Hypotension;
• Severe bradyarrhythmias;
• decompensated heart failure;
• prolongation of the QT Syndrome.

Dosing and administration of ATP.

ATP is injected intramuscularly with 10 mg of a 1% solution once daily in the first days of treatment, then the same dose – twice a day or 20 mg once a day. The course of treatment typically lasts 30 to 40 days. If necessary, repeat the treatment after a 1-2 months’ break.

The drug is administered intravenously, 10-20 mg for 5 seconds. Infusion is repeated in 2-3 minutes if necessary.

 Side effects.

• Headache;
• Tachycardia;
• Increased urine output;
• Flushing of the face.