Diclo-F, eye drops 0.1%, 5 ml

Composition

Active ingredient:

diclofenac sodium – 1 ml

Auxiliary substances:

benzalkonium chloride-0.1 mg;

disodium edetate-1 mg;

boric acid-15 mg;

trometamine-6 mg;

polyoxyl-35-castor oil-20 mg;

povidone-15 mg

sodium hydroxide or hydrochloric acid – up to pH 7.7;

water for injection – up to 1 ml

. Pharmacological action

 It has anti-inflammatory, analgesic and antipyretic effects. The mechanism of action is due to non-selective inhibition of COX-1 and -2 activity, which leads to suppression of PG synthesis in the inflammatory focus.

Diclofenac reduces eye inflammation, which can occur as a result of infection, injury or surgery; reduces miosis during surgery, reduces the synthesis of PG and their content in the moisture of the anterior chamber.

Pharmacokinetics

When instilling eye drops, diclofenac is absorbed into the systemic circulation. However, the concentration of the drug substance reached in the blood is significantly lower than the detection limit and has no clinical significance.

Indications

• inhibition of miosis during cataract surgery;
• treatment of non-infectious conjunctivitis;
• treatment and prevention of inflammatory processes after surgical interventions on the eyeball;
• prevention of cystic macular edema after cataract surgery;
• treatment and prevention of post-traumatic inflammatory process in penetrating and non-penetrating wounds of the eyeball (as an adjunct to local antibacterial therapy).

Use during pregnancy and lactation

There are no data on the use of the drug during pregnancy and lactation. When using NSAIDs in the third trimester of pregnancy, the risk of fetal circulatory disorders may increase. Use in pregnant and lactating mothers is possible only as prescribed by the attending physician, if the expected therapeutic effect exceeds the risk of possible side effects.

There are no reliable data on the use of the drug in children, so the drug should be used in this category of patients only if the expected benefit exceeds the potential risk.

Contraindications

• violation of hematopoiesis of unknown origin;
• hypersensitivity to acetylsalicylic acid or other NSAIDs;
• erosive and ulcerative processes in the gastrointestinal tract in the acute stage;
• hypersensitivity to diclofenac or auxiliary components of the drug.

It is used with caution in epithelial herpetic keratitis (including in the anamnesis), in diseases that cause blood clotting disorders (including hemophilia, prolongation of bleeding time, tendency to bleed), as well as in elderly patients.

Side effects

 In rare cases-burning of the eyes, blurred visual perception (immediately after instillation); clouding of the cornea (thorn), iritis.

Allergic reactions: itchy eyes, hyperemia, angioedema of the face, fever, chills, photosensitization, skin rash (mainly erythematous, urticaria), erythema multiforme, nausea, vomiting.

Interaction

Concomitant use of this drug with diflunisalum (since bleeding from the gastrointestinal tract may develop) and other NSAIDs, including acetylsalicylic acid in large doses (3 g or more per day), sulfonylureas, methotrexate is not recommended.

Use together with lithium preparations, digitoxin, indirect anticoagulants leads to an increase in their effect.

If necessary, it can be used simultaneously with other eye drops, including those containing corticosteroids. At the same time, the interval between applications should be at least 5 minutes to prevent leaching of active substances by subsequent doses.

How to take, course of administration and dosage

Topically.

To inhibit intraoperative miosis, it is instilled into the conjunctival sac for 2 hours with an interval of 30 minutes (4 times) before surgery.

To prevent cystic edema of the macula,1 drop is instilled 3-4 times a day for 2 weeks after surgery.

Other indications: 1 drop 3-4 times a day, depending on the severity of the condition. The course of treatment can last from 1 to 2 weeks.

Special instructions

 Patients using contact lenses should use Diclo-F only when the lenses are removed and put them back on 15 minutes after instillation of the drug.

The bottle must be closed after each use. Do not touch the tip of the pipette to the eye.

Influence on the ability to drive motor vehicles and manage mechanisms

During the treatment period, it is necessary to refrain from engaging in potentially dangerous activities that require increased concentration of attention and speed of psychomotor reactions.

Form of production

Clear solution from colorless to light yellow.

Storage conditions

In a dark place, at a temperature not exceeding 30 °C (do not freeze)

Shelf life

2 years

Active ingredient

Diclofenac

Conditions of release from pharmacies

By prescription

Dosage form

eye drops

Description

Children as prescribed by a doctor, Adults as prescribed by a doctor

Indications

Corneal injuries, Conjunctivitis, Inflammatory Eye Diseases, Eye Burns

Weight

Weight: 10 g.