Pentasa, retard pills 500 mg, 50 pcs.

Composition

1 tablet contains:

Active ingredient:

mesalazine 500 mg;

Auxiliary substances:

povidone;

ethylcellulose;

magnesium stearate;

talc;

MCC up to 750 mg

. Pharmacological action

Pentasa is an anti-inflammatory.

Pentasa reduces the formation of leukotrienes and cytokinins, neutralizes free radicals, and inhibits leukocyte chemotaxis.

Indications

Non-specific ulcerative colitis; Crohn’s disease.

Use during pregnancy and lactation

During pregnancy and lactation, it is prescribed only in cases where the positive effect exceeds the risk of possible side effects.

Contraindications

Hypersensitivity (including to salicylates, etc. components of the drug); severe violations of liver and kidney function.

Side effects

Abdominal discomfort, nausea, vomiting, headache, diarrhea, skin rash in the form of urticaria or eczema;

very rarely-muscle and joint pain, temporary hair loss, liver and kidney function disorders, pericarditis, myocarditis, pancreatitis, changes in blood formula (leukopenia, granulocytopenia, thrombocytopenia, anemia).

Interaction

When used concomitantly, Pentas enhances the hypoglycemic effect of sulfonylurea derivatives, the ulcerogenicity of corticosteroids, the toxicity of methotrexate and the effect of anticoagulants.

When used simultaneously, Pentas weakens the activity of furosemide, spironolactone, sulfonamides, rifampicin.

Simultaneous use of Pentas increases the effectiveness of uricosuric drugs.

When used concomitantly, Pentasa slows down the absorption of cyancobalamin.

How to take, course of administration and dosage

Inside, without chewing, if possible swallowing whole (to facilitate swallowing, divide into several parts or dissolve in water or juice immediately before ingestion), the dose is selected individually.

Adults with exacerbation of ulcerative colitis or Crohn’s disease-usually up to 4 g / day in several doses; maintenance dose-2 g/day in several doses for ulcerative colitis and 4 g/day in several doses for Crohn’s disease; children over 2 years — usually 20-30 mg/kg / day in several doses.

Overdose

Symptoms: nausea, vomiting, gastralgia, weakness, drowsiness.

Treatment: gastric lavage, administration of laxatives, symptomatic therapy.

Special instructions

Treatment of patients with impaired liver or kidney function is possible only after assessing the degree of their severity.

Renal function ( blood creatinine) should be monitored regularly throughout the course of treatment and especially at the beginning of treatment.

If you suspect the development of pericarditis, myocarditis and changes in the blood formula, you should stop treatment. Manifestations of the above-mentioned adverse reactions may include severe pathological changes in blood composition – increased bleeding, subcutaneous hemorrhage, sore throat and fever; with pericarditis and / or myocarditis – fever and pain behind the sternum in combination with shortness of breath.

In some cases of an allergic reaction to sulfasalazine, intolerance to Pentasa may also develop (risk of allergy to salicylates).

Patients who are “slow acetylators” have an increased risk of developing side effects.

Possible staining of urine and tear fluid in yellow-orange color, staining of soft contact lenses.

Use in patients with impaired liver function: The drug is contraindicated in patients with severe hepatic insufficiency.

Use in patients with impaired renal function: The drug is contraindicated in patients with severe renal insufficiency.

Effect on the ability to drive vehicles and manage mechanisms: The drug does not affect the ability to drive vehicles and manage mechanisms.

Form of production

Coated tablets

Storage conditions

At a temperature not exceeding 25 °C

Shelf life

3 years

Active ingredient

Mesalazine

Conditions of release from pharmacies

By prescription

Dosage form

of long-acting tablets

Description

For adults as directed by your doctor

Indications

Crohn’s Disease, Colitis

Weight

Weight: 68 gr.