Human Chorionic Gonadotropin (HCG) ampoules

Structure and Composition:

1 vial of lyophilized powder for solution for injection containing human chorionic gonadotropin of 500 or 1000, or 1500 IU together with the solvent (sodium chloride isotonic 0.9% in 1 ml ampoules) in paper cartons 5 sets.

Characteristic:

White or almost white powder.

Pharmachologic effect:

It has gonadotropic primarily luteinizing action. In women, it promotes ovulation, hormonal activity and the formation of the corpus luteum. Men stimulates the interstitial cells of the sex glands, in the first place, Leydig cells, thereby enhancing the synthesis of testosterone and spermatogenesis in part, activates development of sexual organs and secondary sexual characteristics, while cryptorchidism contributes to lowering the testicles.

Testimony:

The decline of gonadal function in men and women, due to a violation of the hypothalamus and pituitary gland activity: mezhutochno- pituitary insufficiency (Simmonds disease, Sheehan syndrome, panhypopituitarism any etiology, hypophyseal syndrome, pituitary dwarfism with symptoms of sexual infantilism, hypogonadotropic hypogonadism with signs evnuhoidizma), anovulatory dysfunction ovarian and associated infertility, late puberty, habitual and threatened abortion in the I trimester of pregnancy, dysfunctional uterine bleeding in women of childbearing age, bilateral cryptorchidism in children with unilateral cryptorchidism after surgical treatment if there are signs evnuhoidizma, differential diagnosis of primary and secondary hypogonadism in men.

Contraindications:

Pituitary tumors, inflammatory diseases of the genital system, hormone-active tumors of the genital glands, lack of sexual glands (congenital or after surgery), early menopause, thrombophlebitis, breast-feeding.

Application of pregnancy and breastfeeding:

At the time of treatment should stop breastfeeding.

Side effect:

Allergic reactions, headache, depression, increase in testicular, located in the inguinal canal, preventing their further omission of precocious puberty (during prolonged treatment or use at high doses in male adolescents with impaired physical and sexual development), degeneration of the sexual glands (at unreasonably long-term use of the drug in cryptorchidism, especially if surgery is indicated), atrophy of seminiferous tubules (due to inhibition of the production of FSH in stimulation by estrogen and androgen production), reduce the number of sperm in the ejaculate (the abuse of the drug in men).

Drug Interactions:

Used in conjunction with menopausal gonadotropin in the treatment of infertility.

Dosage and administration:

V / m, in doses 500-3000 IU / day.

Men – 2-3 times a week for 4 weeks courses at intervals of 4-6 weeks. 3-6 courses carried out for 6-12 months for diagnostic purposes – at 1500-3000 IU / day for 5 days.

Women with anovulatory cycles, starting with the 10-12 day cycle – 3000 IU 2-3 times at intervals of 2-3 days or 1500 IU 6-7 times a day.

In pituitary dwarfism with symptoms of sexual infantilism – by 500-1000 IU 1-2 times a week for 1-2 months repeat courses.

If cryptorchidism children up to 10 years – 500-1000 IU, 10-14 years – 1500 IU 2 times a week for 4-6 weeks repeated courses.

Overdose:

Women may occur ovarian hyperstimulation syndrome increases with their size.

Precautionary measures:

Be wary appointed to boys in puberty, patients with coronary artery disease, hypertension, kidney disease, asthma, migraine.

Special instructions:

Do not use too long because of the possible formation of antibodies and suppress the gonadotropic functions of the pituitary gland.

In women with ovarian hyperstimulation syndrome occurs, discontinue administration of the drug.