Expiration date: 03/2020.
Active substance: Fluconazole.
Fluconazole 1 capsule contains 50 mg or 150 mg
1 capsule (150 mg) and 7 Capsules (50 mg) in a package
Fluconazole – group of antifungal triazole derivatives. It inhibits the synthesis of ergosterol, disrupting the permeability of the cell wall. Active against Candida spp., Microsporum spp., Cryptococcus neoformans, Trichophyton spp.
Cryptococcosis (including cryptococcal meningitis), systemic candidiasis, mucosal candidiasis, vaginal candidiasis, prevention of fungal infections in patients with lowered immunity (including in AIDS patients).
Fungal infections of the skin, including tinea pedis, body, groin, pityriasis versicolor, onychomycosis.
Deep endemic mycoses, including coccidioidomycosis, paracoccidioidomycosis, sporotrichosis and histoplasmosis in patients with normal immunity.
Dosing and Administration
Individual. Depending on the indication daily dose is 50-400 mg, the multiplicity of application – 1 time / day. If the kidney function dose of fluconazole must be reduced.
From the digestive system: nausea, abdominal pain, diarrhea, flatulence.
CNS: headache, dizziness.
Allergic reactions: skin rash, anaphylactic reactions.
Pregnancy, the age of 1 year, increased sensitivity to fluconazole and triazole compounds.
Fluconazole should be used with caution in patients with severe hepatic or renal function.
Therapy can be started until culture results and other laboratory tests. However, anti-infectious therapy should be ‘corrected accordingly when the results of these studies will be known.
While the use of coumarin anticoagulants there is an increase in prothrombin time.
Fluconazole increases the half-life of oral hypoglycemic agents – sulfonylureas (hlorpropanid, glibenclamide, glipizide, tolbutamide) in healthy people. The combined use of fluconazole and oral hypoglycemic agents in patients with diabetes may be, however, the physician should bear in mind the possibility of hypoglycemia.
In an application with rifampicin marked shortening of the half-life of fluconazole.
In a dry, dark place at a temperature no higher than 25 ° C.
Shelf life – 3 years.