Iodomarin 100, pills 0.1 mg, 100 pcs.

Composition

Composition for 1 tablet:

Active ingredient: potassium iodide — 0.131 mg (which corresponds to 0.1 mg of iodine);Auxiliary substances: lactose monohydrate, magnesium hydroxycarbonate, gelatin, sodium carboxymethyl starch, colloidal silicon dioxide, magnesium stearate.

Pharmacological action

Pharmacotherapeutic group: thyroxine synthesis regulator-iodine preparationATX code: H 0 ZSA

Pharmacological properties

Pharmacodynamics

Iodine is a vital trace element that is a component of the thyroid hormones thyroxine and triiodothyronine. Thyroid hormones are involved in the development of all organs and systems, in the regulation of metabolic processes in the body: they are responsible for the exchange of proteins, fats, carbohydrates and energy in the body, regulate the activity of the brain, nervous and cardiovascular systems of the genital and mammary glands, as well as the growth and development of the child.

Iodine deficiency is especially dangerous for children, adolescents, pregnant and lactating women.

Pharmacokinetics

SuctionWhen taken orally, potassium iodide is almost completely absorbed in the small intestine.

DistributionThe average volume of distribution for healthy people is approximately 23 liters (38% of body weight). The plasma concentration of iodine normally ranges from 0.1 to 0.5 mcg / dl. It accumulates in the thyroid gland, salivary glands, mammary glands, and stomach tissues. The concentration in saliva, gastric juice and breast milk is approximately 30 times higher than in blood plasma.

DeductionExcreted by the kidneys, the concentration of iodine in the urine relative to creatinine (mcg/g) is an indicator of its entry into the body.

Indications

• prevention of iodine-deficient diseases, including endemic goiter (especially in pregnant and lactating women);
• prevention of recurrent goiter after its surgical removal or after the completion of goiter treatment with thyroid hormone preparations;
• treatment of diffuse euthyroid goiter in newborns, children, adolescents and young adult patients.

Use during pregnancy and lactation

During pregnancy and lactation, the need for iodine increases, so it is especially important to use the drug Yodomarin® 100 in sufficient doses to ensure an adequate intake of iodine in the body. Potassium iodide passes through the placenta and into breast milk. If a nursing woman is taking potassium iodide, additional administration of the drug to children who are breastfed is not required.

The use of the drug during pregnancy and lactation is possible only in the recommended doses. When conducting therapy, it is necessary to take into account the amount of iodine that comes from food.

Contraindications

• hypersensitivity to potassium iodide and/or any auxiliary substance in the composition of the drug;
• symptomatic hyperthyroidism;
• subclinical hyperthyroidism — at doses greater than 150 mcg of iodine per day;
• a solitary toxic thyroid adenoma and functional autonomy of the thyroid gland (focal and diffuse), nodular toxic goiter (with the exception of preoperative therapy the purpose of the blockade of the thyroid gland);
• lactose intolerance, lactase deficiency, a syndrome of glucose-galactose malabsorption;
• herpetiformis (senile) dermatitis Duhring.

The drug should not be used for hypothyroidism, except in cases where the development of the latter is caused by a pronounced iodine deficiency. The use of the drug should be avoided during therapy with radioactive iodine, the presence or suspicion of thyroid cancer.

Side effects

Rarely, allergic reactions can occur: skin rash, angioedema.

Interaction

Iodine deficiency increases and excess iodine decreases the effectiveness of antithyroid therapy for hyperthyroidism. In this regard, before or during treatment of hyperthyroidism, it is recommended to avoid any iodine intake as much as possible. On the other hand, antithyroid drugs inhibit the conversion of Iodine to an organic compound in the thyroid gland and, thus, can cause goiter formation.

Substances that enter the thyroid gland by the same mechanism as iodides can compete with iodine and inhibit its uptake by the thyroid gland (for example, perchlorate, which also inhibits the recycling of iodides inside the thyroid gland). Iodine uptake may also be reduced when using drugs that do not enter the thyroid gland themselves, for example, thiocyanate in concentrations exceeding 5 mg/dl.

Iodine uptake by the thyroid gland and its metabolism are stimulated by endogenous and exogenously administered thyroid-stimulating hormone (TSH).

Concomitant treatment with high doses of Iodine and lithium salts may contribute to goiter and hypothyroidism. High doses of potassium iodide in combination with potassium-sparing diuretics can lead to hyperkalemia.

How to take, course of administration and dosage

When determining the required dose of Yodomarin® 100, regional and individual characteristics of iodine intake with food should be taken into account. This is especially important when prescribing the drug to newborns and children under 4 years of age.

Prevention of iodine deficiency diseases:Newborns and children: 50-100 mcg of iodine per day (1/2-1 tablet of Yodomarin® 100);Teenagers and adults: 100-200 mcg of iodine per day (1-2 tablets of Yodomarin® 100);During pregnancy and lactation: 100-200 mcg of iodine per day (1-2 tablets of Yodomarin® 100).

Prevention of recurrent goiter after its surgical removal or after completion of goiter treatment with thyroid hormone preparations:100-200 mcg of iodine daily (1-2 tablets of Yodomarin® 100).

Treatment of euthyroid goiter:Newborns and children: 100-200 mcg of iodine per day (1-2 tablets of Yodomarin® 100);Adolescents and young adult patients: 200 mcg of iodine per day (2 tablets of Yodomarin® 100).

The daily dose of the drug should be taken in one dose, after a meal, with a sufficient amount of liquid. When prescribing the drug to newborns and children under 3 years of age, it is recommended to dissolve the tablet in a small amount (1 tablespoon) of boiled water at room temperature.

The use of the drug for preventive purposes is carried out for, as a rule, several months or years, and often throughout life.

For the treatment of goiter in newborns,2-4 weeks are usually sufficient; in children, adolescents, and adults, it usually takes 6-12 months or more.

The duration of treatment is determined by the doctor.

Overdose

Symptoms: coloration of the mucous membranes in brown color, reflex vomiting (in the presence of starch-containing components in food, vomit becomes blue), abdominal pain and diarrhea (blood may be present in the stool). In severe cases, dehydration and shock may occur. In rare cases, esophageal stenosis has occurred. Fatal cases were observed only after taking large amounts of iodine (30-250 ml of iodine tincture).

In rare cases, prolonged overdose of potassium iodide can lead to the development of so-called “iodism”, i. e. iodine intoxication: a metallic taste in the mouth, swelling and irritation of the mucous membranes (runny nose, conjunctivitis, gastroenteritis, bronchitis). Potassium iodide can activate latent inflammatory processes, such as tuberculosis. It is possible to develop edema, erythema, acne and bullous rash, hemorrhages, fever and irritability.

Treatment of acute intoxication: gastric lavage with a solution of starch, protein or 5% sodium thiosulfate solution until all traces of iodine are removed. Symptomatic treatment of water-electrolyte balance disorders, anti-shock therapy.

Treatment for chronic intoxication: elimination of potassium iodide.

Treatment of iodine-induced hypothyroidism: elimination of potassium iodide, normalization of metabolism with the help of thyroid hormones.

Treatment of iodine-induced thyrotoxicosis: in mild forms, treatment is not required; in severe forms, thyrostatic therapy is required (the effect of which is always delayed). In severe cases (thyrotoxic crisis), intensive care, plasmapheresis or thyroidectomy is necessary.

In the case of hyperthyroidism, we cannot talk about an overdose as such, since hyperthyroidism can also be caused by an amount of iodine that is normal in other countries.

Description

round flat-cylindrical tablets of white or almost white color, with a chamfer and a risk on one side.

Special instructions

It should be borne in mind that hyperkalemia may develop in patients with renal insufficiency during therapy with the drug. Before starting therapy, it is necessary to exclude the presence of hyperthyroidism or nodular toxic goiter in the patient, as well as the presence of these diseases in the anamnesis. In the presence of a predisposition to autoimmune thyroid diseases, the formation of antibodies to thyroperoxidase is possible. Saturation of the thyroid gland with iodine can prevent the accumulation of radioactive iodine used for therapeutic or diagnostic purposes. In this regard, it is not recommended to take the drug before performing actions using radioactive iodine.

Influence on the ability to drive vehicles and other mechanisms

The use of the drug Yodomarin ® 100 does not affect the ability to drive vehicles and mechanisms.

Form of production

Tablets 0.1 mg.50 or 100 tablets in dark glass vials, with a plastic plug with a shock absorber.1 bottle with instructions for use of the drug in a cardboard box.

Storage conditions

At a temperature not exceeding 25 °C. Keep out of reach of children!

Shelf

life is 3 years. Do not use after the expiration date.

Active ingredient

Potassium iodide

Dosage form

Tablets

Weight

Weight: 36 gr.