Ketoconazole DC, pills 200 mg 10 pcs.

Composition

1 tablet contains:

Active ingredient:

ketoconazole 200 mg,

excipients:

lactose 40 mg,

corn starch 25 mg,

pregelatinized starch 12 mg,

microcrystalline cellulose 7.5 mg,

polyvinylpyrrolidone 12.5 mg,

magnesium stearate 5 mg,

sodium starch glycolate 10 mg

Pharmacological action

Ketoconazole DS is an antifungal agent that has activity against dermatophytes, yeast fungi, dimorphic fungi and eumycetes.

It is also active against staphylococci and streptococci.

The mechanism of action consists in inhibiting the synthesis of ergosterol in fungi.

Prevents the transformation of Candida albicans blastospores into invasive forms.

Indications

It is used to treat the following diseases:

• dermatophytosis, onychomycosis caused by blastomycetes, hyphomycetes;
• vaginal candidiasis, cutaneous-mucosal candidiasis, multicolored lichen;
• systemic mycoses;
• mycoses of the gastrointestinal tract and genitourinary system;
• for the prevention of mycoses in patients with reduced immunological resistance of the body.

Contraindications

• Individual intolerance to the components of the drug.
• Pregnancy and lactation.
• Patients with acute or chronic liver diseases.

Side effects

A temporary decrease in the level of testosterone in the blood plasma.

In rare cases, nausea, constipation, stomach pain, flatulence, gastrointestinal bleeding, diarrhea, headache, dizziness occur.

Interaction

When ketoconazole is co-administered with rifampicin and isoniazid, there is a decrease in the concentration of ketoconazole in blood plasma.

Concomitant use of ketoconazole with cyclosporine, indirect anticoagulants and methylprednisolone may increase their plasma concentrations.

How to take, course of administration and dosage

Adults – 3.3-6.6 mg / kg of body weight per day.

Children – 1-2 tablets per day.

The course of treatment is from two weeks to several months.

Special instructions

With prolonged use, it is necessary to monitor the condition of the liver.

In case of liver diseases, the drug should be stopped.

Children should be taken with caution: with prolonged use, it causes inhibition of cortisol synthesis and vitamin D metabolism.

Form of production

Tablets

Storage conditions

Store in a dry place, protected from light, at temperatures below 25 °C

Shelf life

3 years

Active ingredient

Ketoconazole

Conditions of release from pharmacies

By prescription

Dosage form

Tablets

Weight

Weight: 16 gr.