Revalgin, pills, 100 pcs.

Composition

1 tablet contains:

metamizole 500 mg,

fenpiverinium bromide 0.1 mg,

pitofenone hydrochloride 5 mg

Pharmacological action

Spasmoanalgesic. A combination drug, which includes a non-narcotic analgesic-metamizole sodium (analgin), a myotropic antispasmodic agent-pitofenone hydrochloride and an m-holinoblokiruyushchy agent-fenpiveriiia bromide.

Metamizole has analgesic, antipyretic and weak anti-inflammatory effects.

Pitofenone, like papaverine, has a direct myotropic effect on the smooth muscles of internal organs and causes its relaxation.

Fenpiverinium bromide has an additional antispasmodic effect on smooth muscles due to its m-holinoblocking effect.

Indications

• pain syndrome (mild or moderate) with spasms of smooth muscles of internal organs: renal colic, spasm of the ureter and bladder;
• biliary colic, intestinal colic;
• biliary dyskinesia, postcholecystectomy syndrome, chronic colitis;
• algodismenorrhea, pelvic diseases.

For short-term treatment: arthralgia, myalgia, neuralgia, sciatica.

As an auxiliary drug: pain syndrome after surgical interventions and diagnostic procedures.

Contraindications

Pills:

• hypersensitivity (including to pyrazolone derivatives),
• inhibition of bone marrow hematopoiesis,
• severe hepatic and / or renal insufficiency,
• glucose-6-phosphate dehydrogenase deficiency,
• tachyarrhythmias,
• severe angina pectoris,
• decompensated CHF,
• angle-closure glaucoma,
• prostatic hyperplasia (with clinical manifestations),
• intestinal obstruction,
• megacolon,
• collapse.

Ampoules:

• the oppression of bone marrow hematopoiesis;
• stable and unstable angina;
• congestive heart failure in the stage of decompensation;
• severe liver or kidney disease;
• deficiency of glucose-6-phosphate dehydrogenase;
• tachyarrhythmia;
• acute intermittent porphyria;
• form-closure glaucoma;
• prostatic hyperplasia (clinical manifestations);
• ileus and megacolon;
• collapse;
• pregnancy (I trimester and the last 6 weeks);
• lactation;
• early childhood (up to 3 months or weighing less than 5 kg);
• hypersensitivity to pyrazolones derivatives (phenylbutazone) and other components of the drug.

With caution and under the supervision of a doctor, the drug should be used in patients with impaired liver or kidney function, with a tendency to hypotension, bronchial asthma, increased individual sensitivity to NSAIDs or non-narcotic analgesics (including “aspirin triad” in the anamnesis).

Children and adolescents under 18 years of age should use the drug only as prescribed by a doctor.

Side effects

In therapeutic doses, the drug is usually well tolerated.

Sometimes allergic reactions (skin rash, pruritus, very rarely – anaphylactic shock, urticaria), angioedema are possible.

In isolated cases-a burning sensation in the epigastric region, dry mouth, headache.

Possible dizziness, decreased blood pressure, tachycardia, cyanosis.

With prolonged use-hematopoietic disorders: thrombocytopenia, leukopenia, agranulocytosis (may be manifested by the following symptoms: unmotivated fever, chills, sore throat, difficulty swallowing, stomatitis, as well as the development of vaginitis or proctitis phenomena).

With a tendency to bronchospasm, it is possible to provoke an attack.

In very rare cases – malignant exudative erythema (Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell’s syndrome).

Rarely ( usually with prolonged use or high doses) – impaired renal function, oliguria, anuria, proteinuria, interstitial nephritis, red eye staining.

Very rarely: decreased sweating, paresis of accommodation, difficulty urinating.

Local reactions: with intravenous administration, infiltrates at the injection site are possible.

All side effects should be reported to your doctor.

Interaction

Simultaneous use Revalgin with other non-narcotic analgesics can lead to a mutual increase in toxic effects.

Tricyclic antidepressants, oral contraceptives, and allopurinol disrupt the metabolism of metamizole in the liver and increase its toxicity. Barbiturates, phenylbutazone, and other inducers of microsomal liver enzymes weaken the effect of metamizole.

Concomitant use with cyclosporine reduces the level of the latter in the blood.

Sedatives and tranquilizers enhance the analgesic effect of Revalgin.

If you need to use these and other medications at the same time, you should consult your doctor.

How to take, course of administration and dosage

Adults and adolescents over 15 years of age: 1-2 tablets 2-3 times a day.

The maximum daily dose is 6 tablets. Duration of admission – no more than 5 days.

• Children aged 6-8 years are prescribed 1/2 tablet.
• Children aged 9-12 years – 3/4 tablets.
• Children aged 13-15 years – 1 tablet.

The frequency of reception is 2-3 times/day.

Tablets should be taken orally, preferably after a meal.

Overdose

Symptoms: vomiting, decreased blood pressure, drowsiness, confusion, nausea, epigastric pain, impaired liver and kidney function, convulsions.

Treatment: gastric lavage, administration of activated charcoal, symptomatic therapy.

Special instructions

Do not use for relief of acute abdominal pain (until the cause is determined).

During treatment with the drug Revalgin is not recommended to take ethanol.

Parenteral administration is usually used in emergency cases (renal or hepatic colic) and in cases when oral administration is impossible (or absorption from the gastrointestinal tract is impaired). Special care is required when introducing 2 ml of the solution or more (risk of a sharp decrease in blood pressure). Intravenous injection should be carried out slowly, in a supine position and under the control of blood pressure, heart rate and respiratory rate.

With prolonged (more than a week) use of the drug, it is necessary to monitor the picture of peripheral blood and the functional state of the liver.

Influence on the ability to drive motor vehicles and manage mechanisms

During treatment with the drug, it is not recommended to drive vehicles or engage in other potentially dangerous activities that require rapid physical and mental response.

Form of production

Tablets

Storage conditions

Store in a dry place at a temperature not exceeding 25°C, out of the reach of children.

Shelf

life is 3 years.

Active ingredient

Metamizole sodium, Pitofenone, Fenpiverinium bromide

Dosage form

Tablets

Description

For adults, Children as prescribed by a doctor, Children over 5 years of age, Pregnant women only in the second trimester as prescribed by a doctor

Indications

Cold, Colitis, Trigeminal Neuralgia, Sciatica, Sciatica, Migraine, Gastrointestinal Spasm, Biliary Dyskinesia, Osteoarthritis and Arthritis, Lumbago, Rheumatoid Arthritis

Weight

Weight: 108 g.