Yohimbine (Tablets) Instructions for Use

Marketing Authorization Holder

Vifitech, CJSC (Russia)

ATC Code

G04BE04 (Yohimbine)

Active Substance

Yohimbine (BAN)

Dosage Form

Yohimbine

Tablets 5 mg: 50 or 60 pcs.

Dosage Form, Packaging, and Composition

Tablets are white or almost white, round, flat-cylindrical in shape, with a bevel.

Excipients: lactose monohydrate – 75 mg, potato starch – 19 mg, calcium stearate – 1 mg.

10 pcs. – contour cell packs (5) – cardboard packs.
20 pcs. – contour cell packs (3) – cardboard packs.

Clinical-Pharmacological Group

Drug used for erectile dysfunction

Pharmacotherapeutic Group

Erectile dysfunction treatment agent – alpha-adrenoblocker

Pharmacological Action

Alpha-adrenoblocker, acts primarily on presynaptic central and peripheral α₂-adrenoreceptors.

It enhances blood flow to the pelvic organs (including the genitals).

It increases libido and potency.

It has an antidiuretic effect, causes an increase in heart rate and blood pressure.

Pharmacokinetics

It is rapidly and completely absorbed from the gastrointestinal tract.

C_max is reached in 1.3 hours.

10 minutes after oral administration, it crosses the blood-brain barrier and is detected in the cerebrospinal fluid; about 17% is determined in brain tissues within 6 hours.

It is metabolized in the liver.

T_1/2 is 0.6 hours.

Indications

Treatment of psychogenic and functional impotence, bladder atony, male menopause.

ICD codes

Dosage Regimen

Take tablets orally with a full glass of water.

Initiate therapy with a single dose of 5 mg (one tablet).

Administer the dose three times daily.

Gradually increase the single dose to 10 mg (two tablets) based on individual tolerance and therapeutic response.

Do not exceed the maximum daily dose of 30 mg.

The standard course of treatment lasts from three to ten weeks.

Adhere strictly to the dosing schedule prescribed by your physician.

Discontinue use and consult your doctor if severe adverse reactions occur.

Adverse Reactions

Possible dizziness, headache, anxiety, migraine, hand tremor, vomiting, diarrhea, gastralgia, decrease or increase in blood pressure, orthostatic hypotension, tachycardia.

Contraindications

Hypersensitivity to yohimbine; arterial hypertension or hypotension, coronary artery disease, liver and/or kidney diseases, simultaneous use of adrenergic stimulants.

Use in Pregnancy and Lactation

Not applicable.

Use in Hepatic Impairment

Contraindicated in liver diseases.

Use in Renal Impairment

Contraindicated in kidney diseases.

Geriatric Use

It should be prescribed with caution to elderly patients to avoid worsening of concomitant diseases.

Special Precautions

Use with caution in gastric or duodenal ulcer, mental illnesses.

Patients with a possible risk of a sudden decrease in blood pressure and development of tachycardia should be monitored.

Effect on the ability to drive vehicles and mechanisms

During the treatment period, patients should avoid driving vehicles and other activities requiring high concentration and speed of psychomotor reactions.

Drug Interactions

Mutual weakening of the effect with simultaneous use of yohimbine with clonidine.

Yohimbine reduces the effectiveness of antihypertensive drugs and alprazolam.

Yohimbine enhances the effect of antidepressants.

Clomipramine increases the concentration of yohimbine in blood plasma.

Storage Conditions

Store at 2°C (36°F) to 25°C (77°F). Keep in original packaging, protected from light. Keep out of reach of children.

Dispensing Status

Rx Only

Important Safety Information

This information is for educational purposes only and does not replace professional medical advice. Always consult your doctor before use. Dosage and side effects may vary. Use only as prescribed.