Amoxicillin, 500 mg capsules, 16 pcs.

Composition

Active ingredient-amoxicillin 500.00 mg (in the form of amoxicillin trihydrate 573.9 mg);

excipients-magnesium stearate 9.20 mg,

microcrystalline cellulose PH 102-26.90 mg;

capsule No.0:

gelatin up to 96 mg;

capsule cap:

titanium dioxide [E 171] – 0.49920 mg,

dye sunny sunset yellow [E 110] – 0.13774 mg,

dye azorubin [E 122] – 0.13336 mg;

capsule body:

titanium dioxide [E 171] — 0.57600 mg,

iron oxide yellow dye [E 172] – 0.26899 mg.

Pharmacological action

Amoxicillin is a broad-spectrum antibiotic from the group of semi-synthetic penicillins, which has a broad spectrum of action.

The effect of amoxicillin occurs very quickly. Like other penicillin antibiotics, it inhibits cell wall synthesis.

Amoxicillin acts bactericidal and is active against gram-positive cocci (Staphylococcus spp., Streptococcus pneumoniae, group A, B, C, G, H, I, M); gram-negative cocci (Neisseria meningitidis,

N. gonorrhoeae); gram-negative bacilli (Escherichia coli, Shigella spp., Klebsiella spp., Proteus mirabilis, Salmonella, CamPylobacter, Haemophilus influenzae, Bordetella pertussis, Chlamydia).

Amoxicillin is active against all microorganisms sensitive to penicillin G: Erysipelothrix rhysiopathiae, Corynebacterium, Bacillus anthracis, Actinomycetes, Streptobacilli, Spirillium minus, Pastereulla multocida, Listeria, Spirochaeta (Leptospira, Treponema, Borrelia), etc.,

and various anaerobic microorganisms (including peptococci, Peptostreptococcus, Clostridium, and fuzobakterii).

Strains of microorganisms that produce beta-lactamases are resistant to Amoxicillin.

Amoxicillin is acid-resistant and therefore effective when administered orally.

Indications

Infectious and inflammatory diseases caused by microorganisms sensitive to amoxicillin:

• infections of the upper respiratory tract (tonsillopharyngitis, sinusitis, acute otitis media);
• infections of the lower respiratory tract (acute bacterial bronchitis, exacerbation of chronic bronchitis, community-acquired pneumonia);
• infections of the genitourinary system (pyelonephritis, pyelitis, cystitis, urethritis, endometritis, cervicitis, gonorrhea);
• abdominal infection (cholangitis, cholecystitis);
• Helicobacter pylori eradication in patients with peptic ulcer of stomach and duodenum (always in combination with other drugs);
• infections of skin and soft tissues (erysipelas, impetigo, secondarily infected dermatoses);
• leptospirosis, listeriosis;
• Lyme disease;
• infections of the gastrointestinal tract (enterocolitis, typhoid, dysentery, salmonellosis, caused by Salmonella typhi sensitive to ampicillin, salmonellosis;
• prophylaxis of bacterial endocarditis in surgical procedures in the oral cavity and upper respiratory tract.

Use during pregnancy and lactation

There are currently no data on the possible embryotoxic, teratogenic or mutagenic effects of the drug when taken during pregnancy.

Amoxicillin is found in breast milk, which should be considered when prescribing Amoxicillin during lactation.

Contraindications

• Hypersensitivity to amoxicillin, other beta-lactam antibiotics (other penicillins, cephalosporins, monobactams, carbapenems) or any components of the drug;
• infectious mononucleosis, lymphocytic leukemia;
• children under 3 years of age (for this dosage form).

With caution:Allergic reactions (including bronchial asthma, pollinosis, hypersensitivity to acetylsalicylic acid) in the anamnesis, diseases of the gastrointestinal tract in the anamnesis (especially colitis associated with the use of antibiotics), renal failure, pregnancy and lactation.

Side effects

Allergic reactions: 

urticaria, skin rash, erythema, exanthema, angioedema, rhinitis, conjunctivitis, photosensitization; rarely-fever, joint pain, eosinophilia; in rare cases-anaphylactic shock.

Other services: 

it is possible to develop superinfection with the appearance of loose stools, nausea.

Interaction

Antacids, glucosamine, laxatives, aminoglycosides-slow down and reduce the absorption of amoxicillin; ascorbic acid increases absorption.

Ethanol reduces the rate of absorption of amoxicillin.

Amoxicillin increases digoxin absorption.

Probenecid, competing for the elimination pathway, slows down the elimination of amoxicillin, which leads to an increase in the concentration of amoxicillin in blood plasma. Similarly, amoxicillin interacts with diuretics, nonsteroidal anti-inflammatory drugs (oxifenbutazone, phenylbutazone, acetylsalicylic acid, Indometacin).

Amoxicillin reduces the clearance of methotrexate, which can lead to the development of toxic effects of the latter.

When taking allopurinol at the same time, the risk of allergic skin reactions increases.

Amoxicillin, by suppressing the intestinal microflora, helps to reduce the synthesis of vitamin K and the prothrombin index, which increases the effectiveness of indirect anticoagulants and drugs that produce paraaminobenzoic acid in the process of metabolism, which ultimately increases the risk of breakthrough bleeding.

Amoxicillin reduces the effectiveness of oral contraceptives, because in conditions of altered intestinal biocenosis, estrogen reabsorption decreases.

When amoxicillin is co-administered with bactericidal antibiotics (aminoglycosides, cephalosporins, cycloserine, vancomycin, rifampicin), a synergistic antibacterial effect is observed. Bacteriostatic drugs (macrolides, chloramphenicol, lincosamides, tetracyclines, sulfonamides), on the contrary, weaken the bactericidal effect of amoxicillin.

Metronidazole increases the antibacterial activity of amoxicillin.

How to take, course of administration and dosage

Adults are prescribed 500 mg 3 times a day.

In severe cases of the disease – 1 g 3 times / day.

Children aged 5-10 years are prescribed 250 mg 3 times/day, children 2-5 years-125 mg 3 times/day, children under 2 years-at the rate of 20 mg/kg of body weight (divided into 3 doses).

The course of treatment is 5-12 days. The interval between meals is 8 hours.

For the treatment of acute uncomplicated gonorrhea,3 g is prescribed once (in combination with 1 g of probenecid).

Women are recommended to repeat this dose every other day.

Special instructions

In patients with hypersensitivity to cephalosporins, carbapenems, the possibility of cross-allergy should be considered.

For severe gastrointestinal infections accompanied by persistent diarrhea or vomiting, amoxicillin should not be administered orally due to the possibility of poor absorption.

The use of antibiotics is ineffective in the treatment of acute respiratory viral infections.

Special care should be taken in patients with allergic diathesis or bronchial asthma and hay fever (hay fever), a history of gastrointestinal diseases (especially colitis associated with the use of antibiotics).

If you are taking Amoxicillin for a long time, you should simultaneously prescribe nystatin, levorin or other antifungal drugs.

With prolonged use of high doses of the drug in patients, liver and kidney function indicators should be monitored, and general urine tests should be performed. It is advisable to monitor the picture of peripheral blood.

Form of production

Capsules

Storage conditions

Store in a dry place, protected from light, at room temperature.

Shelf

life is 2 years.

Active ingredient

Amoxicillin

Conditions of release from pharmacies

By prescription

Dosage form

of the capsule

Description

Children over 10 years of age, Adults as prescribed by a doctor, Pregnant women as prescribed by a doctor, Children as prescribed by a doctor

Indications

Sore Throat, Respiratory Tract Infections, Intestinal Infections, Otitis Media, Skin Infections, Pharyngitis, Bronchitis, Urinary Tract Infections

Weight

Weight: 21 g.