Artoxan lyophilizate for preparation of, 20 mg vial 3 pcs + solvent

Composition

Lyophilized powder for preparation of solution for injection complete with solvent.

1 bottle of the drug contains

Active ingredient:

tenoxicam 20 mg.

Auxiliary substances:

mannitol,

ascorbic acid,

disodium edetate,

trometamine,

sodium hydroxide,

hydrochloric acid, etc

.1 ampoule with solvent contains water for injection 2 ml

. Pharmacological action

DRUG CODE FOR ATX M 01 AS

PHARMACOTHERAPY GROUP

Nonsteroidal anti-inflammatory drugs. Oxycams.

PHARMACOLOGICAL PROPERTIES

Artoxan is an effective nonsteroidal anti-inflammatory drug (NSAID) with a powerful anti-inflammatory, analgesic and less pronounced antipyretic effect. The properties of the drug are due to the inhibition of both isoforms of the cyclooxygenase enzyme, which leads to a violation of arachidonic acid metabolism and a blockade of prostaglandin synthesis.

The anti-inflammatory effect is due to a decrease in capillary permeability (limits exudation), stabilization of lysosomal membranes (prevents the release of lysosomal enzymes that cause tissue damage), inhibition of the synthesis or inactivation of inflammatory mediators (prostaglandins, histamine, bradykinin, lymphokines, complement factors). Reduces the amount of free radicals in the focus of inflammation, inhibits chemotaxis and phagocytosis. Inhibits the proliferative phase of inflammation, reduces post-inflammatory sclerosis of tissues; has a chondroprotective effect.

The drug reduces pain sensitivity in the focus of inflammation and acts on the thalamic centers of pain, has a desensitizing effect (with prolonged use). In rheumatic diseases, it relieves joint pain at rest and during movement, reduces morning stiffness and joint swelling, improves joint function and increases the amount of joint movement.

Pharmacokinetics

It has a long half-life of 60-75 h. It easily passes through histohematic barriers, penetrates well into synovial fluid. It is characterized by high bioavailability-100%.

Indications

Inflammatory and degenerative diseases of the musculoskeletal system, accompanied by pain syndrome:

– rheumatoid arthritis, gouty arthritis, ankylosing spondylitis (Ankylosing spondylitis);

– infectious non-specific polyarthritis;

– osteoarthritis, osteochondrosis;

– tendinitis, bursitis, myositis, periarthritis;

– arthralgia, neuralgia, myalgia, ischalgia, lumbago;

– injuries, burns.

Contraindications

-hypersensitivity to tenoxicam or other NSAIDs;

– erosive and ulcerative lesions of the gastrointestinal tract;

– gastrointestinal bleeding;

– pregnancy;

– lactation;

– childhood;

– “aspirin triad”;

– severe liver and kidney function disorders;

– renal failure;

– heart failure;

– blood diseases.

Side effects

From the digestive system: abdominal pain and discomfort, nausea, flatulence.

Nervous system disorders: dizziness, headache.

Allergic reactions: pruritus, urticaria, erythema, Stevens-Johnson and Lyell syndromes. Laboratory parameters: increased plasma concentrations of creatinine and urea, increased activity of “hepatic” transaminases.

Interaction

The drug enhances the effect of lithium preparations, indirect anticoagulants (it is necessary to monitor the prothrombin index).

When used with diuretics, the possibility of sodium and water retention in the body should be taken into account.

How to take, course of administration and dosage

It is intended for intramuscular or intravenous administration.

It is prescribed at a dose of 20 mg once a day, maintenance dose: 10 mg per day.

With severe pain, you can increase the dose to 40 mg once a day.

For acute attacks of gouty arthritis: 20 mg 2 times a day for the first 2-3 days, then 20 mg 1 time a day for 5 days.

Overdose

No cases of overdose were observed.

Special instructions

Long-term treatment with Artoxan requires monitoring of liver and kidney function. It is possible to increase the bleeding time, which should be taken into account during surgical interventions.

With extreme caution, the drug is prescribed to persons under 18 years of age due to the lack of sufficient information about their use of tenoxicam.

INFLUENCE ON THE ABILITY TO DRIVE A CAR AND OTHER MECHANISMS During treatment with the drug, care should be taken when driving vehicles and engaging in other potentially dangerous activities that require increased concentration of attention and speed of psychomotor reaction.

Product form

lyophilized powder of green-yellow color, solvent: colorless transparent liquid.

Active ingredient

Tenoxicam

Conditions of release from pharmacies

By prescription

Dosage form

solution for injection and infusion

Description

For adults as directed by your doctor

Indications

Bursitis, Periarthritis, Osteoarthritis, Arthritis, Rheumatoid Arthritis

Weight

Weight: 50 gr.