Aspirin cardio, pills 100 mg, 56 pcs.

Composition

1 tablet contains

acetylsalicylic acid 100 mg

. Pharmacological action

Aspirin cardio has antipyretic, analgesic and anti-inflammatory effects, as well as reduces platelet aggregation. The main mechanism of action of acetylsalicylic acid is irreversible inactivation of the cyclooxygenase enzyme, resulting in impaired synthesis of prostaglandins, prostacyclines and thromboxane.

Due to a decrease in prostaglandin production, the pyrogenic effect of prostaglandins on the thermoregulatory centers decreases. In addition, the sensitizing effect of prostaglandins on sensitive nerve endings decreases (which leads to a decrease in their sensitivity to pain mediators).

Irreversible violation of the synthesis of thromboxane_{A2 in platelets} causes the antiplatelet effect of acetylsalicylic acid. At the same time, it should be taken into account that acetylsalicylic acid also blocks cyclooxygenase of endothelial cells, in which prostacyclin is synthesized, which has antiplatelet activity. However, cyclooxygenase of endothelial cells is less sensitive to the action of acetylsalicylic acid and, unlike the platelet enzyme, is blocked reversibly.

The use of tablets coated with a film coating that is resistant to the action of gastric juice reduces the frequency of side effects from the stomach.

Sodium bicarbonate, which is a part of effervescent tablets, neutralizes free hydrochloric acid in the stomach (up to pH 6.0-7.0), which reduces the irritating effect of acetylsalicylic acid on the gastrointestinal mucosa.

Indications

– prevention of stroke (including in patients with transient disorders of cerebral circulation);

– prevention of transient disorders of cerebral circulation;

– prevention of thromboembolism after surgery and invasive procedures on vessels (including coronary artery bypass grafting, endarterectomy of the carotid arteries, arteriovenous bypass grafting, angioplasty of the carotid arteries);

– prevention of acute myocardial infarction in the presence of risk factors (including diabetes, hyperlipidemia, hypertension, Smoking, older age) and repeated myocardial infarction;

unstable angina;

– prevention of deep vein thrombosis and thromboembolism of the pulmonary artery and its branches (including during prolonged immobilization as a result of extensive surgery).

Use during pregnancy and lactation

The drug is contraindicated for use in the first and third trimesters of pregnancy. The use of high-dose salicylates in the first trimester is associated with an increased incidence of fetal malformations (cleft palate, heart defects). In the third trimester, the use of salicylates in high doses (more than 300 mg/day) causes inhibition of labor, premature closure of the arterial duct in the fetus, increased bleeding in the mother and fetus, and the appointment immediately before delivery can cause intracranial hemorrhages, especially in premature babies.

Prescribing the drug in the second trimester of pregnancy is possible only after careful assessment of the intended benefit to the mother and the potential risk to the fetus.

During lactation, with prolonged use or when taking acetylsalicylic acid in high doses, breastfeeding should be discontinued.

Accidental intake of salicylates during lactation does not require discontinuation of breastfeeding. Salicylates and their metabolites are excreted in small amounts in breast milk.

Contraindications

– interactions with methotrexate at a dose of 15 mg per week;– renal failure; hepatic failure;– severe heart failure in the stage of decompensation;– arterial hypertension;– angina;– enlargement of the thyroid gland; and III trimester of pregnancy;– lactation (breastfeeding);– acute and recurrent erosive and ulcerative gastrointestinal disease; hemorrhagic diathesis;– bronchial asthma induced by ingestion of salicylates and NSAIDs;– hypersensitivity to acetylsalicylic acid, other salicylates or to any components of the drug.

The drug is not prescribed to children under the age of 15 years with acute respiratory diseases caused by viral infections, because of the risk of developing Reye’s syndrome (encephalopathy and acute fatty liver with acute development of liver failure). With caution, the drug should be prescribed for gout, hyperuricemia; patients with a history of ulcerative lesions of the gastrointestinal tract (including peptic ulcer of the stomach and duodenum) or gastrointestinal bleeding, impaired renal and liver function, bronchial asthma, chronic respiratory diseases, hay fever, polyposis of the nasal mucosa; with allergic reactions to drugs (including NSAIDs), in the second trimester of pregnancy.

Side effects

From the gastrointestinal tract: nausea, anorexia, epigastric pain are possible; in some cases (especially with frequent and prolonged use of the drug) – erosive and ulcerative lesions of the gastrointestinal tract, latent blood loss from the gastrointestinal tract, signs of gastrointestinal bleeding (tarry stools).

From the hematopoietic system: very rarely – thrombocytopenia, anemia (due to hidden bleeding from the gastrointestinal tract). Allergic reactions: rarely (especially in patients with bronchial asthma) – skin rash, bronchospasm.

Interaction

When used together, Aspirin Cardio enhances the effects of methotrexate by reducing its renal clearance and displacing it from plasma protein bonds.

When used concomitantly, Aspirin Cardio enhances the effect of heparin and indirect anticoagulants by disrupting platelet function and displacing indirect anticoagulants from their plasma protein bonds.

Aspirin Cardio, when used in combination, enhances the effect of thrombolytic and antiplatelet medications (including ticlopidine).

Aspirin Cardio increases the concentration of digoxin in the blood plasma and enhances its effects by reducing renal clearance.

Aspirin Cardio enhances the effect of hypoglycemic drugs (insulin and sulfonylurea derivatives) due to the hypoglycemic effect of acetylsalicylic acid and the displacement of sulfonylurea derivatives from the bond with plasma proteins.

When used together, Aspirin Cardio weakens the effect of uricosuric drugs (benzbromarone).

Simultaneous use of corticosteroids increases the excretion of salicylates.

How to take, course of administration and dosage

Aspirin cardio is prescribed orally.

For prevention of suspected acute myocardial infarction, the recommended dose is 100-200 mg / day or 300 mg every other day. The first tablet is recommended to be chewed for faster absorption.

For the prevention of first-time acute myocardial infarction in the presence of risk factors, the recommended dose is 100 mg / day or 300 mg every other day.

For the prevention of recurrent myocardial infarction, unstable angina, for the prevention of stroke, transient cerebrovascular accident and thromboembolic complications after vascular surgery, the drug is prescribed at a dose of 100-300 mg / day. For the prevention of deep vein thrombosis and thromboembolism of the pulmonary artery and its branches, the recommended dose of the drug is 100-200 mg / day or 300 mg every other day.

Aspirin Cardio is intended for long-term use, the duration of therapy is set individually.

Aspirin Cardio tablets are taken before meals, washed down with plenty of fluids.

Overdose

Symptoms: moderate overdose – nausea, vomiting, tinnitus, hearing loss, dizziness, confusion; severe overdose-fever, hyperventilation, ketoacidosis, respiratory alkalosis, coma, cardiovascular and respiratory failure, severe hyperglycemia. Overdose is most likely in elderly patients.

Treatment: in case of moderate overdose – reduction of the drug dose; in case of severe overdose-immediate hospitalization for emergency therapy-activated charcoal, gastric lavage, determination of acid-base balance indicators, alkaline and forced alkaline diuresis, hemodialysis, infusion therapy; symptomatic treatment. When performing alkaline diuresis, it is necessary to achieve pH values between 7.5-8. Forced alkaline diuresis should be performed at a salicylate concentration in plasma of more than 500 mg/l (3.6 mmol/l) in adults and 300 mg/l (2.2 mmol/l) in children.

Special instructions

Children and adolescents with diseases associated with hyperthermia, Aspirin should be prescribed only if other drugs are ineffective.

If long-term persistent vomiting occurs when Aspirin is prescribed, this may be a sign of Reye’s syndrome.

Patients with allergic diseases, including bronchial asthma, allergic and hay rhinitis, urticaria, pruritus, mucosal edema and nasal polyps, as well as in combination with chronic respiratory tract infections, patients with hypersensitivity to analgesics and antirheumatic drugs of any type may develop asthma attacks.

During the period of use of the drug, you should refrain from drinking alcohol.

Form of production

Enteric coated tablets.

Storage conditions

At a temperature not exceeding 25 °C

Shelf life

5 years

Active ingredient

Acetylsalicylic acid

Dosage form

of the tablet

Purpose

Pregnant women only in the second trimester as prescribed by a doctor, For adults

Indications

Prevention of heart attacks and strokes, Angina pectoris, Prevention of cerebral circulation disorders, Prevention of thrombosis

Weight

Weight: 19 gr.