Indications
Indications
Prostate cancer – as part of a combination therapy with a GnRH analog or with surgical castration.
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$128.00
Active ingredient: | |
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Dosage form: | |
Indications for use: |
Prostate cancer – as part of a combination therapy with a GnRH analog or with surgical castration.
Individual, depending on the indications and treatment regimen.
Active ingredients:
bicalutamide 150 mg.
Excipients:
corn starch 107 mg,
croscarmellose sodium 19.5 mg,
lactose monohydrate 132.9 mg,
povidone 7.6 mg,
sodium stearyl fumarate 3 mg.
Composition of the film shell:
Opadray II white 12 mg.
Active ingredients:
bicalutamide 150 mg.
Auxiliary substances:
corn starch 107 mg,
croscarmellose sodium 19.5 mg,
lactose monohydrate 132.9 mg,
povidone 7.6 mg,
sodium stearyl fumarate 3 mg.
Composition of the film shell:
Opadray II white 12 mg
Prostate cancer – as part of a combination therapy with a GnRH analog or with surgical castration.
Do not prescribe to female patients.
From the endocrine system: hot flashes, breast tenderness and gynecomastia, decreased libido.
From the digestive system: abdominal pain, diarrhea, nausea, vomiting, increased transaminase levels, jaundice, cholestasis.
From the central nervous system: possible asthenia, depression.
Dermatological reactions: alopecia, restoration of hair growth, itching, dry skin.
Other: hematuria.
When bicalutamide was used for 28 days while taking midazolam, the AUC of midazolam increased by 80%.
When bicalutamide is co-administered with cyclosporine or calcium channel blockers, potentiation or the development of adverse reactions may occur.
Theoretically, it is possible to increase the concentration of bicalutamide in blood plasma when it is used simultaneously with inhibitors of microsomal liver enzymes, which may be accompanied by an increase in the frequency of adverse reactions.
In vitro studies have shown that bicalutamide can displace the coumarin anticoagulant warfarin from the plasma protein binding sites.
Individual, depending on the indications and treatment regimen.
Cases of overdose in humans are not described.
There is no specific antidote. Treatment is symptomatic.
Dialysis is not effective because bicalutamide binds strongly to proteins and is not excreted unchanged by the kidneys. General maintenance therapy and monitoring of vital body functions are indicated.
Use with caution in patients with moderate to severe hepatic impairment, as accumulation of bicalutamide in the body is possible.
Regular monitoring of liver function is required during treatment. In case of severe changes, it is necessary to stop taking bicalutamide.
Film-coated tablets.
Store in a dry place, protected from light, at a temperature not exceeding 25 °C
2 years
Bicalutamide
By prescription
Tablets
For adults as directed by your doctor
Cancer
Weight: 30 gr.
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