Cycloferon, ampoules 12.5%, 2 ml, 5 pcs.

Composition

>1 ml of the solution contains:Active ingredient:meglumine acridon acetate in terms of acridonacetic acid-125 mg; auxiliary substance:water for injection.

Pharmacological action

CYCLOFERON is a low-molecular-weight inducer of interferon, which determines a wide range of its biological activity (antiviral, immunomodulatory, anti-inflammatory, etc. ). The main interferon producing cells after CYCLOFERON administration are macrophages, T-and B-lymphocytes.

Depending on the type of infection, there is a predominance of activity of one or another link of immunity. The drug induces high interferon titers in organs and tissues containing lymphoid elements (spleen, liver, lungs), activates bone marrow stem cells, stimulating the formation of granulocytes.

CYCLOFERON activates T-lymphocytes and natural killer cells, normalizes the balance between subpopulations of T-helper cells and T – suppressors. Increases the activity of alpha-interferons.

CYCLOFERON is effective against tick-borne encephalitis, influenza, hepatitis, herpes, cytomegalovirus, human immunodeficiency virus, papillomavirus and other viruses.

In acute viral hepatitis, CYCLOFERON prevents the transition of diseases to a chronic form.

At the stage of primary manifestations of HIV infection, it helps to stabilize immunity indicators. The drug is highly effective in the complex therapy of acute and chronic bacterial infections (neuroinfections, chlamydia, bronchitis, pneumonia, postoperative complications, urogenital infections, peptic ulcer disease) as a component of immunotherapy.

CYCLOFERON is highly effective in rheumatic and systemic connective tissue diseases, suppressing autoimmune reactions and exerting anti-inflammatory and analgesic effects.

Pharmacokinetics

When the maximum allowable dose is administered, the maximum concentration in the blood is reached in 1-2 hours, after 24 hours the drug is detected in trace amounts. It overcomes the blood-brain barrier. The elimination half-life is 4-5 hours. It does not accumulate in the body with prolonged use.

Indications

In adults in complex therapy:

• HIV infection (stage 2 A – 2 B);
• neuroinfections: serous meningitis and encephalitis, tick-borne borellis (Lyme disease);
• viral hepatitis A, b, C, D;
• herpes and cytomegalovirus infection;
• secondary immunodeficiencies associated with acute and chronic bacterial and fungal infections;
• chlamydia infections;
• rheumatic and systemic connective tissue diseases (rheumatoid arthritis, systemic lupus erythematosus);
• degenerative joint diseases: osteoarthrosis deformans etc.

 In children in complex therapy:

• viral hepatitis A, B, C, D;
• herpetic infection;
• HIV infection (stages 2 A-2 B).

Use during pregnancy and lactation

Contraindicated.

Contraindications

Pregnancy, lactation, children under 4 years of age, individual intolerance to the components of the drug, decompensated cirrhosis of the liver.

Side effects

Allergic reactions.

Interaction

CYCLOFERON is compatible and well combined with all drugs traditionally used in the treatment of these diseases (interferons, chemotherapeutic drugs, etc. ).

Enhances the effect of interferons and nucleoside analogues.

Reduces the side effects of chemotherapy, interferon therapy.

How to take, course of administration and dosage

For adults, Cycloferon is administered intravenously or intravenously 1 time a day according to the basic scheme: every other day. The duration of treatment depends on the disease.

For herpetic and cytomegalovirus infections, the drug is prescribed according to the basic scheme – 10 injections of 250 mg. The total dose is 2.5 g. Treatment is most effective at the beginning of an exacerbation of the disease.

For neuroinfections, the drug is administered according to the basic scheme. The course of treatment is 12 injections of 250-500 mg in combination with etiotropic therapy. The total dose is 3-6 g. Repeated courses are carried out as needed.

With chlamydia infection, treatment is carried out according to the basic scheme. The course of treatment is 10 injections of 250 mg. The total dose is 2.5 g. Repeat the course in 10-14 days. It is advisable to combine Cycloferon with antibiotics.

In acute viral hepatitis A, B, C, D and mixed forms, the drug is administered according to the basic scheme of 10 injections of 500 mg. The total dose is 5 g. With a prolonged course, a second course is carried out in 10-14 days.

In chronic viral hepatitis B, C, D and mixed forms, the drug is administered according to the basic scheme of 10 injections of 500 mg, then according to the maintenance scheme 3 times a week. for 3 months as part of complex therapy. It is recommended in combination with interferons and chemotherapy. Repetition of the course is carried out in 10-14 days.

With HIV infection (stage 2A-2B) the drug is prescribed according to the basic scheme of 10 injections of 500 mg and then according to the maintenance scheme once every three days for 2.5 months. Repeat the course after 10 days.

In immunodeficiency states, the course of treatment consists of 10 injections in / m according to the basic scheme in a single dose of 250 mg. The total dose is 2.5 g. The second course is carried out in 6-12 months.

For rheumatic and systemic connective tissue diseases,4 courses of 5 injections are prescribed according to the basic scheme,250 mg each with a break of 10-14 days. The doctor determines the need for a second course individually.

For degenerative-dystrophic diseases of the joints,2 courses of 5 injections of 250 mg are prescribed with a break of 10-14 days according to the basic scheme. The doctor determines the need for a second course individually.

Children are prescribed Cycloferon IV or IV 1 time a day. The daily therapeutic dose is 6-10 mg / kg of body weight.

In acute viral hepatitis A, B, C, D and mixed forms,15 injections of the drug are performed according to the basic scheme. If the course of infection is prolonged, the course is repeated after 10-14 days.

In chronic viral hepatitis B, C, and D, the drug is administered according to the basic scheme of 10 injections and then according to the maintenance scheme 3 times a week for 3 months as part of complex therapy. It is recommended to use in combination with interferons and chemotherapy.

For HIV infection (stages 2A-2B) prescribe a course of 10 injections according to the basic scheme and then according to the maintenance scheme 1 time in 3 days for 3 months. The second course is carried out in 10 days.

For herpetic infection, a course of 10 injections is carried out according to the basic scheme. While maintaining the replicative activity of the virus, the course of treatment is continued according to the maintenance scheme with the introduction of the drug 1 time in 3 days for 4 weeks.

Special instructions

• CYCLOFERON does not affect the ability to drive vehicles.
• In the treatment of influenza and respiratory viral infections, symptomatic therapy is performed.
• If you have thyroid diseases, you should consult an endocrinologist.

Form of production

Solution for intravenous and intramuscular administration

Storage conditions

In a dark place, at a temperature of 0-25 °C

Shelf life

5 years

Active ingredient

Meglumine Acridone acetate

Conditions of release from pharmacies

By prescription

Dosage form

solution for injection and infusion

Description

For adults as prescribed by a doctor, Children over 4 years of age, Children as prescribed by a doctor

Indications

Flu, Intestinal Infections, Osteoarthritis, Rheumatoid Arthritis, Hepatitis, Immunodeficiency States, Herpes, Colds, Infectious diseases, Chronic infections

Weight

Weight: 27 gr.