Derinat, solution 15 mg/ml 5 ml vials 5 pcs.

Composition

Active ingredient:sodium deoxyribonucleate 1.5 g Excipients: sodium chloride 0.9 g, water for injection-100 ml

Pharmacological action

The drug activates the processes of cellular and humoral immunity. The immunomodulatory effect is due to the stimulation of B-lymphocytes, activation of T-helper cells. Derinat activates the body’s non-specific resistance, optimizing inflammatory responses, and the immune response to bacterial, viral, and fungal antigens. It stimulates reparative and regenerative processes. Increases the body’s resistance to infections, regulates hematopoiesis (helps normalize the number of white blood cells, lymphocytes, granulocytes, phagocytes, platelets). Having a pronounced lymphotropy, Derinat stimulates the drainage and detoxification function of the lymphatic system. Derinat significantly reduces the sensitivity of cells to the damaging effects of chemotherapeutic drugs and radiation therapy. The drug does not have embryotoxic, teratogenic or carcinogenic effects. PHARMACOKINETICSABSORPTION and distributionthe drug is rapidly absorbed and distributed in organs and tissues with the participation of the endolymphatic transport pathway. It has a high tropicity to the organs of the hematopoietic system, takes an active part in cellular metabolism, integrating into cellular structures. In the phase of intensive intake of the drug into the blood, redistribution occurs between plasma and shaped blood elements, in parallel with metabolism and excretion. After a single injection, all pharmacokinetic curves describing changes in the drug concentration in the studied organs and tissues are characterized by a rapid phase of increase and a rapid phase of decrease in concentration in the time interval of 5-24 hours. The half-life (T1 / 2) of intramuscular administration is 72.3 hours. Derinat is rapidly distributed throughout the body, and during daily course use it accumulates in organs and tissues: maximum: – in the bone marrow, lymph nodes, spleen, thymus; to a lesser extent – in the liver, brain, stomach, small and large intestines. The maximum concentration in the bone marrow is determined 5 hours after administration of the drug. The drug overcomes the blood-brain barrier. The maximum concentration of the drug in the brain is reached in 30 minutes. Metabolism and elimination. Derinate is metabolized in the body. It is excreted from the body (in the form of metabolites) partly in the faeces, and, to a greater extent, in the urine according to a biexponential dependence.

Indications

• Radiation injury;
• violation of hematopoiesis;
• mielodepressiya and resistance to cytostatics in cancer patients that developed on the background of cytostatic and/or radiation therapy (stabilization of hematopoiesis, reducing cardio – and myelotoxicity of chemotherapy);
• stomatitis induced cytotoxic therapy,
• gastric ulcer and 12 duodenal ulcer, erosive gastroduodenitis;
• ischemic heart disease;
• occlusive vascular disease of the lower extremities, chronic ischemic disease of the lower extremities stage II – III;
• trophic ulcers, long-unhealed wounds;
• odontogenic sepsis, purulent-septic complications;
• rheumatoid arthritis;
• burn disease;
• preoperative and postoperative periods (in surgery);
• endometritis;
• chlamydia, ureaplasmosis, mycoplasmosis;
• prostatitis;
• chronic obstructive pulmonary disease;
• pulmonary tuberculosis.

Use during pregnancy and lactation

A doctor’s consultation is required. If it is necessary to prescribe the drug during pregnancy, the expected benefit to the mother and the potential risk to the fetus should be evaluated. During lactation, use strictly as prescribed by a doctor.

Contraindications

Hypersensitivity to the components of the drug.

Side effects

Short-term increase in body temperature.

Interaction

Combined use with other medications may increase the therapeutic effect of Derinat.

When used together, Derinat may enhance the effect of anticoagulants.

How to take, course of administration and dosage

Derinat in the form of a solution for injection is prescribed to adults in / m in an average single dose of 75 mg (5 ml of 1.5% solution) with an interval of 24-72 hours.

In CHD,10 injections of the drug are prescribed with an interval of 48-72 hours.

For peptic ulcer of the stomach and duodenum,5 injections are prescribed with an interval of 48 hours.

For cancer – 3-10 injections with an interval of 24-72 hours.

For uterine fibroids and prostatitis – 10 injections with an interval of 24-48 hours.

For tuberculosis – 10-15 injections with an interval of 24-48 hours.

In acute inflammatory diseases-3-5 injections with an interval of 24-72 hours.

For chronic inflammatory diseases – 5 injections with an interval of 24 hours, then 5 injections with an interval of 72 hours.

In children, the multiplicity of intravenous administration of the drug is the same as in adults.

Children under 2 years of age are prescribed the drug in an average single dose of 7.5 mg (0.5 ml of 1.5% solution), in children aged 2 to 10 years, a single dose is determined at the rate of 0.5 ml of the drug per year of life.

Special instructions

To reduce soreness, Derinat is administered intramuscularly slowly, for 1-2 minutes.

Immediately before administration, it is recommended to warm the bottle in your hand to body temperature.

Form of production

Solution for intramuscular administration.

Storage conditions

Store in a dry place, protected from light, at a temperature of 4-18 °C

Shelf life

5 years

Active ingredient

Sodium Deoxyribonucleate

Conditions of release from pharmacies

By prescription

Dosage form

solution for injection

Description

Children as prescribed by a doctor, Adults as prescribed by a doctor

Indications

Burns, Runny nose, Inflammation of the female genital organs, Cold, Flu, Frostbite, Prevention of flu and colds, Hemorrhoids, Sinusitis, Bedsores, Trophic ulcers, Immunodeficiency, Sinusitis

Weight

Weight: 77 g.