Dermovate (Clobetasol) ointment, cream

The composition and form of issue:

Cream. 100 g contains:

of clobetasol propionate 0.05 g

excipients: glycerol monostearate arlacel 165 beeswax substitute 6621 metastability alcohol propylene glycol chlorocresol sodium citrate citric acid monohydrate purified water 

in tubes of 25 g in a box 1 tuba.

Ointment. 100 g contains:

of clobetasol propionate 0.05 g

excipients: propylene glycol sorbitane sesquioleate white soft paraffin to 100 g 

in tubes of 25 g in a box 1 tuba.

Pharmacological action:

Possesses glucocorticoid activity.

Description pharmacological action:

Eliminates edema, hyperemia, itching at the site of application.

Indications:

Psoriasis (excluding widespread plaque), chronic eczema, flat, red diskoidnaya lupus, skin diseases, not amenable to the effects of other steroids.

Contraindications:

Hypersensitivity acne pink and youth perioral dermatitis, skin infection viral (herpes simplex), fungal (candidiasis), bacterial (impetigo) perianal and genital itching dermatosis in children up to 1 year (including dermatitis and rashes with diaper rash).

Application of pregnancy and breast-feeding:

With caution, as sufficient data on the safety of use during pregnancy and breast-feeding no.

Side effects:

With long — term use atrophic changes on the face and other parts of the body (warts, skin thinning, vasodilation), the weakening of the barrier functions of the skin, seldom — emergence of pustular psoriasis.

Method of application and dose:

Externally. Cream and ointment apply a thin layer to affected skin 1-2 times daily until relieved. The treatment should not be more than 4 weeks without an assessment of the need for its continuation. In exacerbations of skin diseases there are repeated short courses of treatment with Dermovate. If you want to continue therapy with glucocorticoids, use less drugs. In particularly resistant cases, especially with hyperkeratosis, inflammatory effect of cream and ointment Dermovate can be strengthened by imposing on the night on the affected area with an occlusive bandage with PE film. After that, the achieved improvement is supported by the use of the drug without occlusive dressings.

Overdose:

Evident signs of hyperadrenocorticism (requiring discontinuation of the drug).

Precautions:

If no improvement in 2-4 weeks should doubt the correctness of the diagnosis. The friends need short refresher courses. Patients with psoriasis can weaken the skin’s barrier function, to appear pustular psoriasis, develop tolerance, relapse. You should avoid long and continuous use in children, especially infants, because it is possible to suppress function of the adrenal cortex. Infants diapers can act like occlusive dressing and increase absorption of corticosteroids. On the face of the drug used for 5 days, and without occlusive dressings. Before applying fresh bandages skin should be clean, as heat and humidity caused hermetic (occlusive) dressings, contribute to the emergence of bacterial infection. Accession bacterial infection requires the use of the drug and the appointment of antimicrobial therapy. The drug should not get in eyes (possible glaucoma). Prolonged use of large quantities (or large areas) may lead to systemic absorption (hyperadrenocorticism).