Flexen, 50 mg capsules, 30 pcs.

Composition

Active ingredient:

ketoprofen 50 mg;

Auxiliary substances:

hydrogenated vegetable oil,

hydrogenated soybean oil,

beeswax.

Capsule shell composition:

gelatin, glycerol, sorbitol, titanium dioxide, sodium ethyl parahydroxybenzoate, sodium propyl parahydroxybenzoate.

Pharmacological action

Flexen is an NSAID derived from propionic acid.

It has analgesic, anti-inflammatory and antipyretic effects. The mechanism of action is associated with inhibition of the activity of COX, the main enzyme of arachidonic acid metabolism, which is a precursor of prostaglandins, which play a major role in the pathogenesis of inflammation, pain and fever.

The pronounced analgesic effect of ketoprofen is due to two mechanisms: peripheral (indirectly, through suppression of prostaglandin synthesis) and central (due to inhibition of prostaglandin synthesis in the central and peripheral nervous systems, as well as the effect on the biological activity of other neurotropic substances that play a key role in the release of pain mediators in the spinal cord).

In addition, ketoprofen has anti-radikinin activity, stabilizes lysosomal membranes, and causes significant inhibition of neutrophil activity in patients with rheumatoid arthritis. Inhibits platelet aggregation.

Indications

Inflammatory diseases of the musculoskeletal system: osteoarthritis, ankylosing spondylitis, gout, rheumatoid arthritis, bursitis, tendosynovitis, sciatica, myalgia, sciatica, bruises and sprains of muscles, tendons and ligaments, edema (symptomatic therapy); pain syndrome (postoperative, post-traumatic pain, pain with bone metastases), renal colic, algodismenorrhea.

Contraindications

Hypersensitivity (including to other NSAIDs), acute gastrointestinal diseases, severe renal and hepatic dysfunction, leukopenia, thrombocytopenia, blood clotting disorders, hemorrhoids and proctitis (suppositories), pregnancy, breast-feeding, children under 15 years of age.

Side effects

From the digestive system: possible stomach pain, nausea, vomiting, diarrhea, flatulence; rarely-bleeding in the gastrointestinal tract; with rectal use-tenesmus, loose stools.

From the central nervous system: rarely-asthenia, headache, dizziness.

Local reactions: with rectal application – burning sensation.

Other: rarely-transient dysuria, skin rash; with external use – allergic skin reactions (pruritus, urticaria).

Interaction

Since ketoprofen binds heavily to proteins, the dose of anticoagulants, diphenylhydantoin or sulfur-containing drugs should be reduced.

How to take, course of administration and dosage

Inside, after eating, without chewing and drinking enough water,50-100 mg 2-3 times a day.

Overdose

Treatment: there is no specific antidote; if necessary, symptomatic therapy is performed.

Form of production

Capsules

Storage conditions

At a temperature not exceeding 25 °C

Shelf life

5 years

Active ingredient

Ketoprofen

Conditions of release from pharmacies

By prescription

Dosage form

of the capsule

Description

For adults as directed by your doctor

Indications

Osteoarthritis, Swelling after injuries and operations, Lumbago, Rheumatoid Arthritis, Osteoarthritis, Myositis, Gout, Bursitis, Trigeminal Neuralgia, Sciatica, Bruises, Arthritis, Osteochondrosis

Weight

Weight: 24 gr.