Penester pills 5 mg, 90 pcs.

Composition

Active ingredient: 

finasteride 5 mg;

Auxiliary substances: 

lactose monohydrate-77.45 mg,

corn starch-40 mg,

povidone K30-3.25 mg,

sodium carboxymethyl starch (type A) – 2.6 mg,

sodium docusate-400 mcg,

magnesium stearate-1.3 mg;

Shell composition:

Hypromellose 2910/5-3.15 mg, macrogol 6000-300 mcg, talc-300 mcg, titanium dioxide-200 mcg, simethicone SE4 emulsion-30 mcg, iron oxide yellow dye-20 mcg

Pharmacological action

Penester is a drug for the treatment of benign prostatic hyperplasia. Finasteride is a synthetic 4-azasteroid compound. It is a competitive and specific inhibitor of the steroid 5-alpha reductase, an intracellular enzyme that converts testosterone to the active androgen 5-dihydrotestosterone.

The growth of prostate tissue and the development of benign hyperplasia are caused by the conversion of testosterone to dihydrotestosterone in prostate cells. Under the influence of the drug, there is a significant decrease in the concentration of dihydrosterone both in the blood plasma and in the gland tissue. Finasteride does not bind to androgen receptors.

As a result of the use of the drug, the size of the prostate gland decreases, and the severity of symptoms associated with prostatic hyperplasia decreases.

The drug does not affect the concentration of plasma lipids, as well as the content of cortisol, estradiol, prolactin, thyroid-stimulating hormone, thyroxine in blood plasma.

Pharmacokinetics

Suction and distribution

After oral administration, finasteride is rapidly absorbed from the gastrointestinal tract. Bioavailability is about 80% and does not depend on food intake. Cmax in blood plasma is reached 1-2 hours after oral administration of the drug. Binding to plasma proteins is about 90%.

Metabolism and elimination

Finasteride is metabolized in the liver and is excreted as metabolites in the urine and faeces.

Pharmacokinetics in special clinical cases

, T1 / 2 in patients over 60 years of age is 6 hours, in patients over 70 years of age it can be prolonged up to 8 hours.

Indications

Benign prostatic hyperplasia (to reduce the size of the prostate gland, increase the maximum rate of urine outflow, and reduce symptoms associated with hyperplasia; reduce the risk of acute urinary retention and the associated likelihood of surgery).

Use during pregnancy and lactation

Women of childbearing age and pregnant women should avoid contact with crushed tablets of Penester, because the ability of the drug to suppress the conversion of testosterone to dihydrotestosterone can cause a violation of the development of the genital organs in the male fetus. Penester tablets are film-coated, so if they are not crushed into powder or their integrity is not violated, contact with the Active ingredient is excluded.

Contraindications

Hypersensitivity, urinary tract obstruction, prostate cancer.

Side effects

From the side of the reproductive system: gynecomastia, breast tenderness, impotence, decreased libido and decreased ejaculate volume.

Other services: allergic reactions.

How to take, course of administration and dosage

The drug is prescribed orally at 5 mg 1 time a day, regardless of food intake.

The duration of therapy before evaluating its effectiveness should be at least 6 months.

In approximately 50% of patients, the disappearance of clinical symptoms occurred during treatment within 12 months.

Special instructions

Before starting treatment, it is necessary to exclude diseases that can simulate benign prostatic hyperplasia, such as infectious prostatitis, prostate cancer, urethral stricture, hypotension of the bladder and a number of changes on the part of the urinary system that occur in certain diseases of the nervous system.

Since the use of finasteride shows a decrease in prostate-specific antigen (by 41% and 48%, respectively, by 6 and 12 months from the start of therapy), patients should be periodically examined during therapy to exclude prostate cancer.

Composition

Tablet Form of production

Storage conditions

Store in a dry place, protected from light, at a temperature not exceeding 25 °C

Shelf life

2 years

Active ingredient

Finasteride

Conditions of release from pharmacies

By prescription

Dosage form

Tablets

Description

For adults as directed by your doctor

Indications

Prostatic Hyperplasia, Prostatitis

Weight

Weight: 30 gr.