Selank, nasal drops 0.15%, 3 ml

Composition

Composition per 1 ml:Active ingredient:Selanka® in terms of 100% substance (threonyl-lysylprolyl-arginyl-prolyl-glycyl-proline diacetate – – 1.5 mg. Auxiliary substances:methylparahydroxybenzoate (nipagin) – 1 mg, purified water up to 1 ml

. Pharmacological action

Pharmacotherapeutic group:

anxiolytic agent (tranquilizer).

ATX code: N05BX

Pharmacological action

Pharmacodynamics

Selank® is a synthesized analog of the endogenous peptide taftzin, which has an original mechanism of neurospecific action on the central nervous system.

Selank® has an anti-anxiety effect with an antidepressant effect; anti-asthenic effect.

Relieves symptoms of anxiety, anxiety, fear, apathy, depression and asthenia.

It has a positive effect on cognitive functions, improves memory, speech, increases attention, activates learning processes, in particular, memorization, analysis and reproduction of information. Normalizes psychomotor reactions.

Under stress, Selank® eliminates emotional and negative stress and stimulates the development of adaptive behavior aimed at achieving useful results.

Pharmacokinetics

Selank® is administered intranasally (nasal drops). The absolute bioavailability of Selank® when administered on the nasal mucosa is 92.8%. The drug is rapidly absorbed from the nasal mucosa and after 30 seconds is detected in the blood plasma, and then quickly distributed to various organs and tissues. Penetrates the brain tissue. The concentration in the blood plasma progressively decreases within 5-5.5 minutes. No unchanged drug or metabolites are detected in the daily urine, which is due to the rapid degradation of Selank® under the influence of tissue peptidases.

Indications

Alarm states:

• unmotivated anxiety, restlessness;

• panic attacks;

• neurasthenia;

• asthenia;

• mood instability;

• sleep disorders;

• decreased willpower, activity initiation, indecision, difficulty making decisions, self-doubt;

• lack of communication;

• adaptation disorders;

Prevention and treatment of stress disorders.

Use during pregnancy and lactation

Contraindicated during pregnancy and lactation.

Contraindications

Individual intolerance to the drug.

Pregnancy, breast-feeding period (no efficacy and safety studies have been conducted).

Children under 18 years of age (no efficacy or safety studies have been conducted).

Side effects

With increased sensitivity to the perception of smell and taste, when the drug gets from the nasal cavity to the pharyngeal mucosa, unpleasant taste sensations may appear. It is possible to develop allergic reactions with individual intolerance.

If any of the side effects listed in the instructions get worse, or you notice any other side effects not listed in the instructions, tell your doctor.

Interaction

Selank® does not affect the effects of drugs that depress and stimulate the central nervous system – haloperidol, pentobarbital, hexobarbital, analeptics.

Selank® can be combined with any psycho-and neuroactive therapy.

Selank® is safe when combined with ethanol-containing products.

If you are taking other medications (including over-the-counter medications), consult your doctor before using Selank®.

How to take, course of administration and dosage

Selank® is applied intranasally, using a bottle capped with a plastic screw cap, or a dropper cap.

If the bottle is sealed with a plastic screw cap, remove the plastic screw cap at the first use and replace it with the supplied pipette with a cap.

Put the drug in the pipette.

Squeeze the required amount of drops of the drug onto the clean mucous membrane of the nasal passage, then pinch the nostril with your finger for a short time.

If the bottle is sealed with a dropper cap, carefully cut off the tip of the pipette, close the pipette tightly with the cap. Before using, turn the bottle upside down so that the liquid fills the entire space of the pipette. Remove the cap. Squeeze the required amount of drops of the drug onto the clean mucous membrane of the nasal passage, then pinch the nostril with your finger for a short time.

Instillation of the drug into the nasal passages is carried out in a sitting position with the head slightly thrown or tilted to one side, after which each nostril is clamped with a finger for a short time.

The effectiveness of absorption may decrease in the presence of increased discharge from the nasal mucosa, so it is recommended to clean the nasal passage before use (instillation).

Dosage: 2 drops in each nasal passage 3 times a day.

The duration of the course of use of the drug is 14 days. If necessary, the course of treatment can be repeated in 1-3 weeks, after consulting a doctor.

Use the drug only according to the method of use and in the doses indicated in the instructions. If necessary, please consult your doctor before using the medicine.

Overdose

No cases of overdose have been reported with the use of Selank®.

Special instructions

Influence on the ability to drive vehicles and other mechanisms that require increased concentration of attention

The lack of hypnosedative and muscle relaxant properties of the drug and the presence of a positive effect on cognitive functions allow Selank to be used in people of various professions, including those requiring increased attention and coordination of movements (vehicle drivers, operators).

Form of production

Nasal drops

Storage conditions

Store in a dark place, at a temperature not exceeding 10 C.

Do not freeze it. The opened bottle should be stored at a temperature of not more than 25 C for no more than 15 days.

Keep out of reach of children.

Shelf

life is 2 years.

Active ingredient

Threonyl-Lysyl-Prolyl-Arginyl-Prolyl-Glycyl-Proline

Dosage form

nasal drops

Weight

Weight: 15 gr.