Xantinol nicotinate, 150 mg/ml ampoule 2ml 10 pcs.

Composition

1 ml Xantinol nicotinate 150 mg

Auxiliary substances:

d/i water (up to 1 ml).

Pharmacological action

The drug combines the properties of theophylline and nicotinic acid: it causes dilation of peripheral blood vessels, improves collateral blood circulation, improves oxygenation and nutrition of tissues, increases oxidative phosphorylation and ATP synthesis.

Xantinol nicotinate improves cerebral circulation and reduces the effects of cerebral hypoxia.

The drug also activates the processes of fibrinolysis, reduces platelet aggregation.

Indications

-obliterating atherosclerosis;

– endarteritis of the vessels of the lower extremities—

– diabetic angiopathy

— – retinopathy;

– acute thrombophlebitis of the superficial and deep veins—

– strombophlebitic syndrome—

– trophic ulcers of the lower extremities:

– bedsores

— – Meniere’s syndrome

— – dermatoses associated with a vascular trophic disorder; –

violation of cerebral circulation.

Contraindications

— acute heart failure, including acute myocardial infarction;

chronic heart failure IIB-III degree;

— mitral stenosis;

arterial hypotension;

— acute haemorrhage;

ulcer disease of stomach and intestine dvenadtsatiperstnoi in the acute phase;

acute renal failure;

— glaucoma;

— childhood;

— pregnancy the first trimester;

— increased individual sensitivity to the components of the drug.

Side effects

Xantinol nicotinate can cause dizziness, low blood pressure, general weakness, a feeling of heat, tingling and redness of the skin of the upper body, especially the neck and head, nausea, anorexia, diarrhea.

These symptoms usually disappear after 10-20 minutes, do not require special treatment and discontinuation of therapy with this drug.

If you experience undesirable effects that are not described in these instructions, and the above-mentioned side effects increase during therapy with this drug, you should immediately inform your doctor about this.

With prolonged administration in high doses, the drug causes changes in glucose tolerance, increased activity of hepatic transaminases, alkaline phosphatase, and hyperuricemia.

Interaction

To avoid a sharp decrease in blood pressure, the drug should not be used simultaneously with antihypertensive agents.

Do not combine with therapy with MAO inhibitors, strofantin.

How to take, course of administration and dosage

In acute disorders of blood supply to tissues, the drug is administered intravenously at 0.3 g (2 ml of 15% solution) 1-3 times / day. Depending on the nature of the disease, the dose can be gradually increased to 0.6-0.9 g (4-6 ml of 15% solution) 2-3 times/day. The duration of treatment is 2-3 weeks.

In acute disorders of peripheral and cerebrovascular circulation Xantinol nicotinate is administered intravenously at a rate of 40-50 drops/ min. To do this,1.5 g (10 ml of a 15% solution) of the drug is diluted in 200-500 ml of a 5% glucose solution or in 200 ml of an isotonic sodium chloride solution, the resulting infusion mixture is administered dropwise for 1.5-4 hours. The infusion can be repeated up to 4 times / day; the duration of treatment is 5-10 days.

Overdose

The drug is low-toxic.

Symptoms: acute overdose of Xantinol nicotinate is accompanied by hypotension, general weakness, dizziness, tachycardia, abdominal pain and vomiting.

Treatment: if symptoms of overdose occur, symptomatic therapy is prescribed.

Special instructions

Xantinol nicotinate causes a nicotine-like syndrome, accompanied by hyperesthesia of the nasal and oral mucosa (sharpens the sensitivity of the olfactory and taste receptors) in this regard, the smell and taste of alcoholic beverages taken during therapy is perceived more sharp and perverted.

Avoid contact with eyes or mucous membranes.

Influence on the ability to drive motor vehicles and manage mechanisms

Large doses of the drug can cause dizziness, weakness and hypotension, and therefore you should refrain from driving a motor vehicle and working with mechanisms.

Form of production

The solution for intravenous and intramuscular administration is colorless, transparent.

Active ingredient

Xantinol nicotinate

Conditions of release from pharmacies

By prescription

Dosage form

solution for injection and infusion

Weight

Weight: 100 gr.