Analgin pills 500 mg, 20 pcs.

Composition

1 tablet contains:Active ingredient:metamizole sodium (analgin) 500 mgsupport substances:sucrose(sugar), potato starch, talc, calcium stearate.

Pharmacological action

Analgin non-selectively blocks cyclooxygenase and reduces the formation of prostaglandins from arachidonic acid, prevents pain extra-and proprioceptive impulses.

Analgin has a weak anti-inflammatory effect, which causes a small effect on water-salt metabolism (sodium and water retention) and the gastrointestinal mucosa.

It has an antispasmodic effect on the smooth muscles of the urinary and biliary tracts. The action develops in 20-40 minutes after ingestion. Pharmacokinetics

It is well and quickly absorbed in the gastrointestinal tract, which ensures the rapid development of the clinical effect. When taken in therapeutic doses, it penetrates into the mother’s milk.

The maximum plasma concentration is reached 1-1.5 hours after oral administration.

In the intestinal wall, it is hydrolyzed to form the active metabolite,4-methyl-amino-antipyrine, which in turn is metabolized to 4-formyl-amino-antipyrine and other metabolites.

The level of binding of the active metabolite to proteins is 50-60%.

Excretion of metabolites passes through the kidneys. In addition, metabolites are excreted in breast milk.

Indications

• Pain (mild to moderate severity): including headache, migraine, toothache, neuralgia, myalgia, radicular syndrome, algomenorrhea; in kidney, liver and biliary colic (in combination with antispasmodic drugs),
• to reduce pain after surgical and diagnostic interventions,
• increased body temperature, “cold”, and other infectious and inflammatory diseases. The expediency of using the drug is decided in each case, depending on the severity, nature and tolerability of the fever.

Contraindications

• hypersensitivity to the pyrazolone derivative (propyphenazone, phenazone or phenylbutazone);
• bronchial asthma induced by acetylsalicylic acid, salicylates or other nonsteroidal anti-inflammatory drugs (NSAIDs);
• bronchoobstructive, rhinitis, urticaria triggered by the ingestion of aspirin or other NSAIDs (including in history), status after conducting CABG;
• oppression blood (agranulocytosis, cytostatic or infectious neutropenia);
• severe liver or kidney disease;hepatic porphyria,
• confirmed hyperkalemia, erosive and ulcerative changes in the mucous membrane of the stomach and 12 duodenal ulcer, active gastrointestinal bleeding, inflammatory bowel disease, anemia, leukopenia;
• hereditary hemolytic anemia associated with deficiency of glucose-6-phosphate dehydrogenase;
• pregnancy (especially in the 1st trimester and in the last 6 weeks);
• lactation;
• children up to age 8 years.

Side effects

In therapeutic doses, the drug is usually well tolerated.

When using Analgin tablets, some patients may experience side effects:

• allergic reactions (skin rash, angioedema; rarely-anaphylactic shock);
• with prolonged use, leukopenia may occur, rarely agranulocytosis.

With a tendency to bronchospasm, it is possible to provoke an attack.

Kidney function may be impaired.

Interaction

Due to the high probability of developing pharmaceutical incompatibility, it should not be mixed with other drugs. Drugs in one syringe.

Concomitant use of analgin with other non-narcotic analgesics can lead to a mutual increase in toxic effects.

Tricyclic antidepressants, oral contraceptives, and allopurinol disrupt the metabolism of analgin in the liver and increase its toxicity.

Barbiturates, phenylbutazone, and other inducers of microsomal liver enzymes weaken the effect of analgin.

Simultaneous use of analgin with cyclosporine reduces the level of the latter in the blood. Sedatives and tranquilizers enhance the analgesic effect of analgin.

How to take, course of administration and dosage

Inside, after meals, adults and children over 14 years of age are prescribed 250-500 mg 2-3 times a day, the maximum single dose is 1000 mg, the daily dose is 3000 mg.

Children 8-14 years old are prescribed 250 mg (1/2 tablet) 2-3 times a day.

The duration of admission without consulting a doctor is not more than 5 days.

Overdose

In case of overdose, consult your doctor.

The following symptoms may occur: nausea, vomiting, stomach pain, oliguria, hypothermia, decreased blood pressure, tachycardia, shortness of breath, tinnitus, drowsiness, delirium, impaired consciousness, acute agranulocytosis, hemorrhagic syndrome, acute renal and/or liver failure, convulsions, paralysis of the respiratory muscles.

Treatment: symptomatic. There is no specific antidote for metamizole sodium. In the conditions of a medical institution – forced diuresis, hemodialysis, with the development of convulsive syndrome – intravenous administration of diazepam and fast-acting barbiturates.

Special instructions

Hypersensitivity reactions may occur in patients with bronchial asthma and hay fever.

With prolonged use (more than 7 days), it is necessary to monitor the picture of peripheral blood. While taking metamizole sodium, agranulocytosis may develop, and therefore, if an unmotivated fever, chills, sore throat, difficulty swallowing, stomatitis, erosive and ulcerative lesions of the oral cavity, vaginitis or proctitis are detected, the drug should be immediately discontinued.

Do not use to relieve acute abdominal pain (until the cause is determined).

To reduce the risk of adverse events from the gastrointestinal tract, the lowest effective dose should be used in the shortest possible course.

When treating patients receiving cytostatic agents, metamizole sodium should be taken only under the supervision of a doctor.

Form of production

Pills.

Storage conditions

In a place protected from light, out of reach of children, at a temperature not exceeding 25°C

Shelf

life is 5 years.

Active ingredient

Metamizole sodium

Dosage form

Tablets

Description

Pregnant women only in the second trimester as prescribed by a doctor, For adults, Children as prescribed by a doctor

Indications

Neuritis, Osteoarthritis, Mucosal Surface Anesthesia, Gallstone Disease, Arthritis, Common Cold, Urolithiasis, Sciatica

Weight

Weight: 20 g.