Flexid, pills 500 mg, 14 pcs.

Composition

1 table. contains:

Active ingredients:

levofloxacin (in the form of hemihydrate) 500 mg;

Auxiliary substances:

lactose monohydrate,

povidone,

sodium carboxymethyl starch,

talc,

colloidal anhydrous silicon dioxide,

croscarmellose sodium,

glyceryl dibegenate;

Shell composition:

hypromellose, giprolose, macrogol 6000, iron oxide yellow, iron oxide red, titanium dioxide, talc

Pharmacological action

Levofloxacin is a broad-spectrum antimicrobial bactericidal drug that blocks DNA gyrase and topoisomerase IV, and suppresses DNA synthesis.

Active against aerobic gram-positive microorganisms:Enterococcus faecalis, Staphylococcus aureus (methicillin-sensitive strains), Staphylococcus haemolyticus (methicillin-sensitive strains), Staphylococcus saprophyticus, Group C and G Streptococcus, Streptococcus agalactiae, Streptococcus pneumoniae, Streptococcus pyogenes; aerobic gram-negative microorganisms: Acinetobacter baumannii, Citrobacter freundii, Eikenella corrodens, Enterobacter aerogenes, Enterobacter agglomerans, Enterobacter cloacae, Escherichia coli, Haemophilus influenzae, Haemophilus parainfluenzae, Klebsiella oxytoca, Klebsiella pneumoniae, Moraxella catarrhalis, Morganella morganii, Pasteurella multocida, Proteus mirabilis, Proteus vulgaris, Providencia rettgeri, Providencia stuartii, Pseudomonas aeruginosa, Serratia marcescens; anaerobic microorganisms: Bacteroides fragilis, Clostridium perfringens, Peptostreptococcus spp. ; other microorganisms: Chlamydia pneumoniae, Chlamydia psittaci, Legionella pneumophila, Mycoplasma pneumoniae.

Aerobic gram-positive microorganisms are intermediate sensitive to the drug: Staphylococcus haemolyticus (methicillin-resistant strains); aerobic gram-negative microorganisms: Burkholderia cepacia; anaerobic microorganisms: Bacteroides ovatus, Bacteroides thetaiotamicron, Bacteroides vulgatus, Clostridium difficile.

They are insensitive to levofloxacin Staphylococcus aureus (methicillin-resistant strains).

Indications

Infections caused by drug-sensitive strains of microorganisms:- ENT infections (acute sinusitis);- lower respiratory tract infections (acute bronchitis, chronic bronchitis, community-acquired pneumonia);- uncomplicated urinary tract and kidney infections;- complicated urinary tract and kidney infections (including pyelonephritis);- prostatitis; – infections of the skin and soft tissues.

Contraindications

-epilepsy; – tendon damage that occurred during previous treatment with fluoroquinolones;— under 18 years of age;— pregnancy; – lactation period (breastfeeding);— hypersensitivity to levofloxacin or other quinolones, and/or to other components of Flexide. You should be careful:— when prescribing levofloxacin in combination with drugs that affect tubular secretion, such as probenecid and cimetidine, especially in the treatment of patients with impaired renal function;— in the treatment of patients with a predisposition to epileptic seizures, during treatment with fenbufen and similar nonsteroidal anti-inflammatory drugs (NSAIDs) or drugs that reduce the threshold of epileptic seizures, such as theophylline;— in patients with latent or obvious violations of glucose-6-phosphate dehydrogenase activity due to the risk of developing hemolytic reactions.

Side effects

The following side effects were classified as follows: very common (>10%), common (1-10%), non-common (0.1-1%), rare (0.01 – 0.1%), very rare (From the digestive system: common – nausea, diarrhea (including blood), increased activity of liver enzymes (ALT, AST); non – common – decreased appetite, vomiting, abdominal pain, dyspepsia, hyperbilirubinemia; rare-enterocolitis, pseudomembranous colitis; very rare-hypoglycemia, hepatitis.

From the nervous system: uncommon-headache, dizziness, sleep disorders; rare-paresthesia, tremor, anxiety, agitation, confusion, convulsions; very rare-hallucinations, extrapyramidal disorders and other coordination disorders.

From the side of the senses: very rare-visual, hearing, olfactory, taste and tactile sensitivity disorders.

From the cardiovascular system: rare-tachycardia, hypotension; very rare-vascular collapse.

Musculoskeletal disorders: rare-arthralgia, myalgia, tendinitis; very rare-tendon rupture (for example, Achilles tendon), muscle weakness (especially important for patients with myasthenia gravis); in some cases – rhabdomyolysis.

From the urinary system: uncommon-hypercreatininemia; very rare-interstitial nephritis, deterioration of renal function up to acute renal failure.

From the blood system and hematopoietic organs: uncommon – eosinophilia, leukopenia; rare-neutropenia, thrombocytopenia; very rare-agranulocytosis; in some cases – hemolytic anemia, pancytopenia.

Allergic reactions: uncommon-pruritus, skin rash; rare-urticaria, bronchospasm, shortness of breath; very rare – angioedema, hypotension, anaphylactic shock, allergic pneumonitis, photosensitization; in some cases – Stevens-Johnson syndrome, toxic epidermal necrolysis (Lyell’s syndrome), erythema multiforme.

Other: uncommon-asthenia; very rare-fever, vasculitis.

How to take, course of administration and dosage

of Flexide is taken orally: regardless of food intake,250-500 mg 1 time a day.

The duration of treatment depends on the indications for use.

If renal function is impaired, adjustment of the administration regimen is required, including dose reduction depending on creatinine clearance.

Form of production

Film-coated tablets

Storage conditions

At a temperature not exceeding 25 °C

Shelf life

3 years

Active ingredient

Levofloxacin

Conditions of release from pharmacies

By prescription

Dosage form

Tablets

Description

For adults as directed by your doctor

Indications

Inflammation of the lungs, Respiratory tract Infections, Tuberculosis, Boils, Skin Infections, Sinusitis, Inflammation of the female genital organs, Urinary tract infections, Infectious diseases, Bronchitis, Sinusitis

Weight

Weight: 22 gr.