Candiderm, cream, 30 g

Composition

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of 1 g of cream contains:

active ingredients: 

Clotrimazole – 10.0 mg

Beclomethasone dipropionate – 0.25 mg

Gentamicin sulfate, equivalent to gentamicin-1 mg

Auxiliary substances: 

Propylene

Glycol Cetomacrogol

Vaseline

Liquid paraffin

Benzyl alcohol

Methylparahydroxybenzoate (methylparaben) 

Propyl Parahydroxy benzoate (propylparaben) 

Butylhydroxytoluene

Sodium Dihydrogen Phosphate Monohydrate

Sodium Hydrophosphate

Purified water

Pharmacological action

Candiderm is an anti-inflammatory, anti-allergic, antibacterial, and antifungal agent.

Clotrimazole has an antifungal effect due to a violation of the synthesis of ergosterol, which is an integral part of the fungal cell membrane. Active against; Trichophyton rubrum, Trichophyton mentagrophytes, Epidermophyton floccosum, Microsporum canis, Candida albicans, Malassezia furfur (Pityrosporum orbiculare).

Beclomethasone has anti-inflammatory, anti-allergic, anti-exudative and antipruritic effects.

It inhibits the accumulation of white blood cells, the release of lysosomal enzymes and inflammatory mediators, inhibits phagocytosis, reduces vascular-tissue permeability, and prevents the formation of inflammatory edema.

Gentamicin is a broad-spectrum antibiotic from the group of aminoglycosides, has a bactericidal effect against Gram-negative bacteria-Pseudomonas aeruginosa, Enterobacter aerogenes, Escherichia coli, Proteus vulgaris, Klebsiella pneumoniae, gram-positive bacteria: Streptococcus spp., Staphylococcus aureus.

Indications

• dermatoses complicated by secondary infection;

• foot epidermophytosis;

• dermatomycoses (including those localized in the groin area) caused by pathogens sensitive to the drug.

Use during pregnancy and lactation

For children, the drug is prescribed only for strict indications and under medical supervision, as it is possible to develop systemic side effects associated with Beclomethasone.

When using the drug on large surfaces and/or under an occlusive dressing, it is possible to suppress the function of the hypothalamic – pituitary – adrenal system and develop symptoms of hypercorticism, there may be a decrease in the excretion of growth hormone, an increase in intracranial pressure.

Contraindications

• hypersensitivity to the components

• of Candiderm, skin tuberculosis,

• skin manifestations of syphilis,

• chickenpox,

• herpes simplex,

• skin reactions after vaccination,

• children under 7 years of age,

• pregnancy,

• lactation,

• open wounds.

Interaction

Interaction of the drug with other drugs was not detected.

How to take, course of administration and dosage

Externally. The cream is applied in a thin layer on the affected areas of the skin 2 times a day (morning and evening).

The duration of treatment depends on the effectiveness and tolerability of the therapy and is usually 2-4 weeks (no more).

For children (7-16 years), the drug is prescribed only strictly as prescribed and under the supervision of a doctor.

Side effects Burning sensation, hyperemia, erythema, peeling, edema, dryness, maceration and atrophy of the skin; striae, hypertrichosis, folliculitis, sweating, urticaria, steroid acne, perioral dermatitis, allergic contact dermatitis, telangiectasia, hypopigmentation, pyoderma, furunculosis.

With prolonged use, systemic side effects are possible, including suppression of the function of the adrenal cortex.

Overdose

If the recommended doses are exceeded, symptoms of hypercorticism may develop: weight gain, edema, hyperthesia, glucosuria, hypokalemia.

Treatment: 

– symptomatic therapy, if necessary, correct the electrolyte balance.

Gradual discontinuation of the drug is recommended.

Special instructions

The drug is not used in ophthalmology.

Do not apply to the skin around the eyes.

In order to increase the effectiveness of therapy, it is possible to use occlusive dressings.

It should be taken into account that this increases the transdermal absorption of Beclomethasone and gentamicin, which leads to an increased risk of systemic side effects.

If persistent bacterial or fungal microflora develops, the drug should be discontinued and appropriate therapy should be prescribed.

It is possible to develop cross-resistance with aminoglycoside antibiotics.

Form of production

Cream for external use

Storage conditions

In a dark place at a temperature not exceeding 25°C. Do not freeze it. Keep out of reach of children.

Shelf life

3 years

Active ingredient

Beklamethasone, Gentamicin, Clotrimazole

Dosage form

cream

Weight

Weight: 45 gr.