Sorbifer Durules, pills 50 pcs.

Composition

Each coated tablet contains bivalent iron sulfate in an amount equivalent to 100 mg of Fe2+and 60 mg of ascorbic acid, as well as: magnesium stearate, povidone K-25, polyethene powder, carbomer 934 R. The shell contains:hypromellose, macrogol 6000, titanium dioxide, iron oxide yellow, paraffin hard.

Pharmacological action

Pharmacotherapy group:preparation Zhelezakod ATX: B03A A07 PHARMACOLOGICAL Propertiespharmacodynamiczhelezo is an essential component of the body, necessary for the formation of hemoglobin and the course of oxidative processes in living tissues. The drug is used to eliminate iron deficiency. Durules technology provides a gradual release of the active ingredient (iron ions) over a long period of time. The plastic matrix of Sorbifer Durules tablets is completely inert in the digestive juice, but completely disintegrates under the action of intestinal peristalsis, when the active ingredient is completely released. Pharmacokineticadurules is a technology that provides a gradual release of the Active ingredient (iron ions), a uniform supply of the drug. Taking 100 mg twice daily provides 30% greater absorption of iron from Sorbifer Durules compared to conventional iron preparations. Iron absorption and bioavailability are high. Iron is absorbed mainly in the duodenum 12 and the proximal jejunum. Binding to plasma proteins -90% or more. It is deposited in the form of ferritin or hemosiderin in hepatocytes and cells of the phagocytic macrophage system, a small amount – in the form of myoglobin in muscles. The elimination half-life is 6 hours.

Indications

• Iron deficiency anemia.
• Iron deficiency.
• Preventive use during pregnancy, lactation and blood donors.

Contraindications

• Hypersensitivity to the components of the drug.
• Esophageal stenosis and / or obstructive changes in the digestive tract.
• Increased iron content in the body (hemosiderosis, hemochromatosis).
• Impaired iron utilization (lead anemia, sideroblastic anemia, hemolytic anemia).
• Children under 12 years of age (due to lack of clinical data).

With caution: peptic ulcer of the stomach and duodenum, inflammatory bowel diseases (enteritis, diverticulitis, ulcerative colitis, Crohn’s disease).

Side effects

Nausea, vomiting, abdominal pain, diarrhea, constipation. The frequency of gastrointestinal side effects may increase with increasing doses from 100 to 400 mg. Rarely (

Interaction

Durules may reduce the absorption of concomitantly administered enoxacin, clodronate, grepafloxacin, levodopa, levofloxacin, methyldopa, penicillamine, tetracyclines, and thyroid hormones. Concomitant administration of Sorbifer Durules and antacids containing aluminum hydroxide and magnesium carbonate may reduce iron absorption. The maximum possible time interval should be maintained between taking Sorbifer Durules and any of these medications. The recommended minimum time interval between doses is 2 hours, except when taking tetracyclines, when the minimum interval should be 3 hours. Sorbifer Durules should not be combined with the following medications: ciprofloxacin, doxycycline, norfloxacin and ofloxacin.

How to take, course of administration and dosage

Coated tablets are taken orally. They can’t be divided or chewed. The tablet should be swallowed whole and washed down with at least half a glass of liquid. Adults and teenagers:Take 1 tablet 1-2 times a day. If necessary, patients with iron deficiency anemia, the dose can be increased to 3-4 tablets per day in two doses (morning and evening) for 3-4 months (until the iron depot in the body is replenished). During pregnancy and lactation:Prevention: 1 tablet per day. Therapeutic dose: 1 tablet 2 times a day (morning and evening). Treatment should be continued until optimal hemoglobin levels are reached. For further replenishment of the depot, it may be necessary to continue taking the drug for another 2 months.

Overdose

Symptoms: abdominal pain, vomiting and diarrhea mixed with blood, fatigue or weakness, hyperthermia, parastesias, pale skin, cold sticky sweat, acidosis, weak pulse, low blood pressure, palpitations. In severe overdose, signs of peripheral circulatory collapse, coagulopathy, hyperthermia, hypoglycemia, liver damage, renal failure, muscle cramps, and coma may occur after 6-12 hours. Treatment:in case of overdose, consult a doctor immediately. It is necessary to wash the stomach, inside a raw egg, milk (for binding iron ions in the gastrointestinal tract) ; enter deferoxamine. Symptomatic therapy.

Special instructions

Darkening of the stool is possible, which is not clinically important. Pregnancy and lactation Sorbifer Durules can be used during pregnancy and lactation.

Product form

coated tablets Sorbifer Durules

Storage conditions

Store in a dry place protected from light, at a temperature not exceeding 20 °C.

Shelf

life is 3 years.

Active ingredient

Iron sulfate, Ascorbic acid

Conditions of release from pharmacies

By prescription

Dosage form

Tablets

Description

Nursing mothers, Children over 12 years of age, Children prescribed by a doctor, Adults prescribed by a doctor, Pregnant women prescribed by a doctor

Indications

Anemia, Iron Deficiency Prevention

Weight

Weight: 67 gr.